Casein kinase 1, alpha 1

Enzyme found in humans
CSNK1A1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5FQD

Identifiers
AliasesCSNK1A1, CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975, casein kinase 1 alpha 1
External IDsOMIM: 600505; MGI: 1934950; HomoloGene: 111694; GeneCards: CSNK1A1; OMA:CSNK1A1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CSNK1A1
Genomic location for CSNK1A1
Band5q32Start149,492,982 bp[1]
End149,551,471 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for CSNK1A1
Genomic location for CSNK1A1
Band18|18 E1Start61,688,345 bp[2]
End61,723,132 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • islet of Langerhans

  • gallbladder

  • ganglionic eminence

  • smooth muscle tissue

  • epithelium of colon

  • ventricular zone

  • nipple

  • Achilles tendon

  • pylorus
Top expressed in
  • renal corpuscle

  • atrioventricular valve

  • cumulus cell

  • medullary collecting duct

  • medial ganglionic eminence

  • left lung lobe

  • Gonadal ridge

  • molar

  • endocardial cushion

  • pineal gland
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • protein kinase activity
  • nucleotide binding
  • protein binding
  • ATP binding
  • kinase activity
  • protein serine/threonine kinase activity
Cellular component
  • cytoplasm
  • centrosome
  • nuclear speck
  • mRNA cleavage and polyadenylation specificity factor complex
  • membrane
  • keratin filament
  • chromosome
  • microtubule organizing center
  • chromosome, centromeric region
  • cytoskeleton
  • beta-catenin destruction complex
  • kinetochore
  • nucleus
  • cytosol
  • cilium
  • cell projection
  • ciliary basal body
  • ribonucleoprotein complex
Biological process
  • regulation of GTP binding
  • Golgi organization
  • phosphorylation
  • cell division
  • protein phosphorylation
  • cell surface receptor signaling pathway
  • peptidyl-serine phosphorylation
  • phagocytosis
  • intermediate filament cytoskeleton organization
  • cell cycle
  • negative regulation of canonical Wnt signaling pathway
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process
  • signal transduction
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • beta-catenin destruction complex assembly
  • regulation of cell shape
  • beta-catenin destruction complex disassembly
  • Wnt signaling pathway
  • cell morphogenesis
  • peptidyl-threonine phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1452

93687

Ensembl

ENSG00000113712

ENSMUSG00000024576

UniProt

P48729

Q6PJ87

RefSeq (mRNA)

NM_001025105
NM_001271741
NM_001271742
NM_001892

NM_146087
NM_001357498
NM_001357499
NM_001357500

RefSeq (protein)

NP_001020276
NP_001258670
NP_001258671
NP_001883

NP_666199
NP_001344427
NP_001344428
NP_001344429

Location (UCSC)Chr 5: 149.49 – 149.55 MbChr 18: 61.69 – 61.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.[5]

Interactions

Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1[6][7] and AXIN1.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113712 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024576 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tapia C, Featherstone T, Gómez C, Taillon-Miller P, Allende CC, Allende JE (Aug 1994). "Cloning and chromosomal localization of the gene coding for human protein kinase CK1". FEBS Letters. 349 (2): 307–12. doi:10.1016/0014-5793(94)00679-2. PMID 8050587. S2CID 19071414.
  6. ^ Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.
  7. ^ Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
  8. ^ Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.

Further reading

  • Veis A, Sfeir C, Wu CB (1998). "Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity". Critical Reviews in Oral Biology and Medicine. 8 (4): 360–79. doi:10.1177/10454411970080040101. PMID 9391750.
  • Giaccia AJ, Kastan MB (Oct 1998). "The complexity of p53 modulation: emerging patterns from divergent signals". Genes & Development. 12 (19): 2973–83. doi:10.1101/gad.12.19.2973. PMID 9765199.
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K


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