Wee1-like protein kinase

Protein-coding gene in the species Homo sapiens
WEE1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1X8B, 2IN6, 2IO6, 2Z2W, 3BI6, 3BIZ, 3CQE, 3CR0

Identifiers
AliasesWEE1, WEE1A, WEE1hu, WEE1 G2 checkpoint kinase
External IDsOMIM: 193525; MGI: 103075; HomoloGene: 31152; GeneCards: WEE1; OMA:WEE1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for WEE1
Genomic location for WEE1
Band11p15.4Start9,573,670 bp[1]
End9,593,457 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for WEE1
Genomic location for WEE1
Band7|7 E3Start109,721,253 bp[2]
End109,742,493 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastric mucosa

  • embryo

  • ganglionic eminence

  • bronchial epithelial cell

  • skin of abdomen

  • corpus epididymis

  • gallbladder

  • lactiferous duct

  • mucosa of urinary bladder

  • stromal cell of endometrium
Top expressed in
  • primitive streak

  • cumulus cell

  • parotid gland

  • endocardial cushion

  • vas deferens

  • pontine nuclei

  • maxillary prominence

  • internal carotid artery

  • foot

  • ureter
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • nucleotide binding
  • protein tyrosine kinase activity
  • protein kinase activity
  • transferase activity
  • magnesium ion binding
  • non-membrane spanning protein tyrosine kinase activity
  • ATP binding
  • protein binding
  • kinase activity
Cellular component
  • nucleolus
  • nucleoplasm
  • cytoplasm
  • nucleus
Biological process
  • cell cycle
  • neuron projection morphogenesis
  • establishment of cell polarity
  • cell division
  • G2/M transition of mitotic cell cycle
  • microtubule cytoskeleton organization
  • peptidyl-tyrosine phosphorylation
  • protein phosphorylation
  • phosphorylation
  • mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • negative regulation of G1/S transition of mitotic cell cycle
  • mitotic cell cycle checkpoint signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7465

22390

Ensembl

ENSG00000166483

ENSMUSG00000031016

UniProt

P30291

P47810

RefSeq (mRNA)

NM_001143976
NM_003390

NM_009516
NM_001355058

RefSeq (protein)

NP_001137448
NP_003381

NP_033542
NP_001341987

Location (UCSC)Chr 11: 9.57 – 9.59 MbChr 7: 109.72 – 109.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.[5]

Function

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.[6]

Interactions

Wee1-like protein kinase has been shown to interact with YWHAB[7] and PIN1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166483 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031016 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647. S2CID 2920330.
  6. ^ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".
  7. ^ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4). UNITED STATES: 211–9. ISSN 1044-9523. PMID 10775038.
  8. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. 12 (5). UNITED STATES: 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.

Further reading

  • Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
  • Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024 (1): 153–67. Bibcode:2004NYASA1024..153K. doi:10.1196/annals.1321.013. PMID 15265780. S2CID 23655886.
  • Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
  • Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
  • Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
  • Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
  • Igarashi M, Nagata A, Jinno S, et al. (1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647. S2CID 2920330.
  • Baldin V, Ducommun B (1995). "Subcellular localisation of human wee1 kinase is regulated during the cell cycle". J. Cell Sci. 108 (6): 2425–32. doi:10.1242/jcs.108.6.2425. PMID 7673359.
  • Watanabe N, Broome M, Hunter T (1995). "Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle". EMBO J. 14 (9): 1878–91. doi:10.1002/j.1460-2075.1995.tb07180.x. PMC 398287. PMID 7743995.
  • McGowan CH, Russell P (1995). "Cell cycle regulation of human WEE1". EMBO J. 14 (10): 2166–75. doi:10.1002/j.1460-2075.1995.tb07210.x. PMC 398322. PMID 7774574.
  • Kharbanda S, Yuan ZM, Taneja N, et al. (1994). "p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.". Oncogene. 9 (10): 3005–11. PMID 8084605.
  • Heald R, McLoughlin M, McKeon F (1993). "Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase". Cell. 74 (3): 463–74. doi:10.1016/0092-8674(93)80048-J. PMID 8348613. S2CID 12091935.
  • McGowan CH, Russell P (1993). "Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15". EMBO J. 12 (1): 75–85. doi:10.1002/j.1460-2075.1993.tb05633.x. PMC 413177. PMID 8428596.
  • Taviaux SA, Demaille JG (1993). "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization". Genomics. 15 (1): 194–6. doi:10.1006/geno.1993.1032. PMID 8432534.
  • Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
  • Zhou BB, Li H, Yuan J, Kirschner MW (1998). "Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6785–90. Bibcode:1998PNAS...95.6785Z. doi:10.1073/pnas.95.12.6785. PMC 22635. PMID 9618490.
  • Taylor WR, DePrimo SE, Agarwal A, et al. (1999). "Mechanisms of G2 arrest in response to overexpression of p53". Mol. Biol. Cell. 10 (11): 3607–22. doi:10.1091/mbc.10.11.3607. PMC 25646. PMID 10564259.
  • Wang Y, Jacobs C, Hook KE, et al. (2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4): 211–9. PMID 10775038.
  • Cichutek A, Brueckmann T, Seipel B, et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)". Cytogenet. Cell Genet. 93 (3–4): 277–83. doi:10.1159/000056998. PMID 11528126. S2CID 25807985.
  • Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.

External links

  • v
  • t
  • e
  • 1x8b: Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824
    1x8b: Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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