BRSK2

Protein-coding gene in the species Homo sapiens
BRSK2
Identifiers
AliasesBRSK2, C11orf7, PEN11B, SAD1, SADA, STK29, BR serine/threonine kinase 2, SAD-A
External IDsOMIM: 609236; MGI: 1923020; HomoloGene: 123829; GeneCards: BRSK2; OMA:BRSK2 - orthologs
EC number2.7.11.26
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for BRSK2
Genomic location for BRSK2
Band11p15.5Start1,389,899 bp[1]
End1,462,689 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for BRSK2
Genomic location for BRSK2
Band7|7 F5Start141,503,488 bp[2]
End141,557,984 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • ganglionic eminence

  • Brodmann area 9

  • prefrontal cortex

  • nucleus accumbens

  • amygdala

  • caudate nucleus

  • putamen

  • anterior pituitary

  • sural nerve
Top expressed in
  • visual cortex

  • superior frontal gyrus

  • cerebellar cortex

  • prefrontal cortex

  • hippocampus proper

  • ganglionic eminence

  • nucleus accumbens

  • primary motor cortex

  • lateral geniculate nucleus

  • temporal lobe
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • ATPase binding
  • ATPase regulator activity
  • metal ion binding
  • kinase activity
  • protein kinase binding
  • magnesium ion binding
  • tau-protein kinase activity
  • protein serine/threonine kinase activity
  • ATP binding
  • tau protein binding
Cellular component
  • centrosome
  • microtubule organizing center
  • perinuclear region of cytoplasm
  • cytoskeleton
  • nucleus
  • cytoplasm
  • endoplasmic reticulum
  • distal axon
Biological process
  • actin cytoskeleton reorganization
  • neuron projection morphogenesis
  • ERAD pathway
  • phosphorylation
  • nervous system development
  • cell division
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  • G2/M transition of mitotic cell cycle
  • peptidyl-serine phosphorylation
  • cell cycle
  • regulation of ATP-dependent activity
  • regulation of retrograde protein transport, ER to cytosol
  • exocytosis
  • apoptotic process
  • establishment of cell polarity
  • regulation of insulin secretion involved in cellular response to glucose stimulus
  • axonogenesis
  • protein phosphorylation
  • neuron differentiation
  • regulation of neuron projection development
  • intracellular signal transduction
  • regulation of axonogenesis
  • microtubule cytoskeleton organization involved in establishment of planar polarity
  • regulation of synaptic vesicle clustering
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9024

75770

Ensembl

ENSG00000174672

ENSMUSG00000053046

UniProt

Q8IWQ3

Q69Z98

RefSeq (mRNA)

NM_001256627
NM_001256629
NM_001256630
NM_001282218
NM_003957

NM_001009929
NM_001009930
NM_001276763
NM_029426

RefSeq (protein)

NP_001243556
NP_001243558
NP_001243559
NP_001269147
NP_003948

NP_001009929
NP_001009930
NP_001263692
NP_083702

Location (UCSC)Chr 11: 1.39 – 1.46 MbChr 7: 141.5 – 141.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BR serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the BRSK2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174672 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053046 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miura K, Masuzaki H, Ishimaru T, Niikawa N, Jinno Y (Jan 1999). "A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5". Journal of Human Genetics. 43 (4): 283–4. doi:10.1007/s100380050092. PMID 9852686.
  6. ^ Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T (Mar 1999). "Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta". Journal of Human Genetics. 44 (1): 1–9. doi:10.1007/s100380050096. PMID 9929968.
  7. ^ "Entrez Gene: BRSK2 BR serine/threonine kinase 2".

Further reading

  • Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703. S2CID 21397515.
  • Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
  • Lu R, Niida H, Nakanishi M (Jul 2004). "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function". The Journal of Biological Chemistry. 279 (30): 31164–70. doi:10.1074/jbc.M404728200. PMID 15150265.
  • Sabater L, Gómez-Choco M, Saiz A, Graus F (Dec 2005). "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis". Journal of Neuroimmunology. 170 (1–2): 186–90. doi:10.1016/j.jneuroim.2005.08.011. PMID 16165222. S2CID 2531035.
  • Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, Ohtsuka T, Takai Y (Apr 2006). "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release". Neuron. 50 (2): 261–75. doi:10.1016/j.neuron.2006.03.018. PMID 16630837. S2CID 15232412.
  • Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K, Wang Y, Yu L (Sep 2006). "BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260". Biochemical and Biophysical Research Communications. 347 (4): 867–71. doi:10.1016/j.bbrc.2006.06.178. PMID 16870137.

External links

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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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