MARK4

Protein-coding gene in the species Homo sapiens
MARK4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5ES1

Identifiers
AliasesMARK4, MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D, microtubule affinity regulating kinase 4
External IDsOMIM: 606495 MGI: 1920955 HomoloGene: 57146 GeneCards: MARK4
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MARK4
Genomic location for MARK4
Band19q13.32Start45,079,288 bp[1]
End45,305,284 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for MARK4
Genomic location for MARK4
Band7|7 A3Start19,158,700 bp[2]
End19,192,746 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • prefrontal cortex

  • parotid gland

  • Region I of hippocampus proper

  • stromal cell of endometrium

  • endothelial cell

  • putamen

  • nucleus accumbens

  • olfactory bulb

  • cingulate gyrus
Top expressed in
  • internal carotid artery

  • external carotid artery

  • lip

  • motor neuron

  • superior frontal gyrus

  • habenula

  • molar

  • cerebellar cortex

  • subiculum

  • submandibular gland
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • microtubule binding
  • kinase activity
  • protein serine/threonine kinase activity
  • tau-protein kinase activity
  • ubiquitin binding
  • protein binding
  • gamma-tubulin binding
  • ATP binding
  • tau protein binding
Cellular component
  • ciliary basal body
  • cytosol
  • centrosome
  • microtubule cytoskeleton
  • neuron projection
  • cytoskeleton
  • cell projection
  • cytoplasm
  • microtubule organizing center
  • gamma-tubulin complex
  • dendrite
  • midbody
Biological process
  • phosphorylation
  • positive regulation of programmed cell death
  • nervous system development
  • protein phosphorylation
  • microtubule bundle formation
  • cell cycle
  • cell division
  • establishment of cell polarity
  • microtubule cytoskeleton organization
  • cell projection organization
  • ciliary basal body-plasma membrane docking
  • intracellular signal transduction
  • cilium organization
  • positive regulation of cilium assembly
  • regulation of centrosome cycle
  • positive regulation of protein localization to centrosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57787

232944

Ensembl

ENSG00000007047

ENSMUSG00000030397

UniProt

Q96L34

Q8CIP4

RefSeq (mRNA)

NM_001199867
NM_031417

NM_172279
NM_001368427

RefSeq (protein)

NP_001186796
NP_113605

NP_758483
NP_001355356

Location (UCSC)Chr 19: 45.08 – 45.31 MbChr 7: 19.16 – 19.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.[5][6][7] MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins (MAP) causing their detachment from microtubules.[8] Detachment thereby increases microtubule dynamics and facilitates a number of cell activities including cell division, cell cycle control, cell polarity determination, and cell shape alterations.[9]

There are four members of the MARK protein family, MARK1-4, which are highly conserved. MARK4 kinase has been shown to be involved in microtubule organization in neuronal cells. Levels of MARK4 are elevated in Alzheimer's disease and may contribute to the pathological phosphorylation of tau protein in this disease.

Interactions

MARK4 has been shown to interact with USP9X[10] and Ubiquitin C.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007047 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030397 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y (Apr 2001). "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis". Neoplasia. 3 (1): 4–9. doi:10.1038/sj.neo.7900132. PMC 1505019. PMID 11326310.
  6. ^ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484.
  7. ^ "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4".
  8. ^ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (April 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell. 89 (2): 297–308. doi:10.1016/s0092-8674(00)80208-1. PMID 9108484.
  9. ^ Naz F, Anjum F, Islam A, Ahmad F, Hassan MI (November 2013). "Microtubule affinity-regulating kinase 4: structure, function, and regulation". Cell Biochemistry and Biophysics. 67 (2): 485–99. doi:10.1007/s12013-013-9550-7. PMID 23471664. S2CID 13507976.
  10. ^ a b Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (April 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains" (PDF). The Biochemical Journal. 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724. S2CID 13038944.

Further reading

  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Beghini A, Magnani I, Roversi G, Piepoli T, Di Terlizzi S, Moroni RF, Pollo B, Fuhrman Conti AM, Cowell JK, Finocchiaro G, Larizza L (May 2003). "The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines". Oncogene. 22 (17): 2581–91. doi:10.1038/sj.onc.1206336. PMID 12735302.
  • Trinczek B, Brajenovic M, Ebneth A, Drewes G (February 2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". The Journal of Biological Chemistry. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
  • Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (March 2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". The Journal of Biological Chemistry. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
  • Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grünewald S, Kuner R, Weber D, Krüger C, Klaussner B, Götz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M (March 2004). "Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4". Journal of Neurochemistry. 88 (5): 1114–26. doi:10.1046/j.1471-4159.2003.02228.x. PMID 15009667. S2CID 44856849.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (March 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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