PCTK3

Protein-coding gene in the species Homo sapiens
CDK18
Identifiers
AliasesCDK18, PCTAIRE, PCTAIRE3, PCTK3, cyclin-dependent kinase 18, cyclin dependent kinase 18
External IDsOMIM: 169190; MGI: 97518; HomoloGene: 1949; GeneCards: CDK18; OMA:CDK18 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CDK18
Genomic location for CDK18
Band1q32.1Start205,504,596 bp[1]
End205,532,793 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CDK18
Genomic location for CDK18
Band1|1 E4Start132,039,975 bp[2]
End132,067,422 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • C1 segment

  • inferior ganglion of vagus nerve

  • apex of heart

  • middle frontal gyrus

  • subthalamic nucleus

  • right auricle

  • corpus callosum

  • pars reticulata

  • left ventricle

  • ventral tegmental area
Top expressed in
  • duodenum

  • molar

  • jejunum

  • pontine nuclei

  • epithelium of stomach

  • intestinal villus

  • dorsomedial hypothalamic nucleus

  • ileum

  • ventral tegmental area

  • lacrimal gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein binding
  • ATP binding
  • kinase activity
  • cyclin-dependent protein serine/threonine kinase activity
  • protein serine/threonine kinase activity
Cellular component
  • nucleus
  • cytoplasm
  • cellular component
Biological process
  • phosphorylation
  • protein phosphorylation
  • regulation of cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5129

18557

Ensembl

ENSG00000117266

ENSMUSG00000026437

UniProt

Q07002

Q04899

RefSeq (mRNA)

NM_002596
NM_212502
NM_212503

NM_008795

RefSeq (protein)

NP_002587
NP_997667
NP_997668

NP_032821

Location (UCSC)Chr 1: 205.5 – 205.53 MbChr 1: 132.04 – 132.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-3 is an enzyme that in humans is encoded by the CDK18 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117266 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID 1437147.
  6. ^ "Entrez Gene: PCTK3 PCTAIRE protein kinase 3".

Further reading

  • Meyerson M, Enders GH, Wu CL, et al. (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
  • Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Herskovits AZ, Davies P (2004). "Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain". Gene. 328: 59–67. doi:10.1016/j.gene.2003.12.011. PMID 15019984.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Herskovits AZ, Davies P (2006). "The regulation of tau phosphorylation by PCTAIRE 3: implications for the pathogenesis of Alzheimer's disease". Neurobiol. Dis. 23 (2): 398–408. doi:10.1016/j.nbd.2006.04.004. PMID 16766195. S2CID 39038607.
  • Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
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Tropomyosin kinase (EC 2.7.11.28)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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