SNF1LK2

Protein-coding gene in the species Homo sapiens
SIK2
Identifiers
AliasesSIK2, LOH11CR1I, QIK, SNF1LK2, SIK-2, salt inducible kinase 2
External IDsOMIM: 608973; MGI: 2445031; HomoloGene: 22875; GeneCards: SIK2; OMA:SIK2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SIK2
Genomic location for SIK2
Band11q23.1Start111,602,449 bp[1]
End111,730,855 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SIK2
Genomic location for SIK2
Band9|9 A5.3Start50,804,101 bp[2]
End50,920,373 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cardia

  • germinal epithelium

  • adipose tissue

  • lower lobe of lung

  • hair follicle

  • subcutaneous adipose tissue

  • stromal cell of endometrium

  • synovial joint

  • parietal lobe

  • islet of Langerhans
Top expressed in
  • brown adipose tissue

  • white adipose tissue

  • mammary gland

  • subcutaneous adipose tissue

  • ascending aorta

  • aortic valve

  • esophagus

  • spermatid

  • superior frontal gyrus

  • atrioventricular valve
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • magnesium ion binding
  • metal ion binding
  • kinase activity
Cellular component
  • cytoplasm
  • nucleus
  • nucleotide-activated protein kinase complex
Biological process
  • protein autophosphorylation
  • protein phosphorylation
  • intracellular signal transduction
  • phosphorylation
  • regulation of insulin receptor signaling pathway
  • cellular response to hormone stimulus
  • negative regulation of TOR signaling
  • cellular response to glucose starvation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23235

235344

Ensembl

ENSG00000170145

ENSMUSG00000037112

UniProt

Q9H0K1

Q8CFH6

RefSeq (mRNA)

NM_015191

NM_178710

RefSeq (protein)

NP_056006

NP_848825
NP_001391943
NP_001391944

Location (UCSC)Chr 11: 111.6 – 111.73 MbChr 9: 50.8 – 50.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.[5][6]

Interactions

SNF1LK2 has been shown to interact with CRTC2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170145 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037112 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico". International Journal of Oncology. 24 (5): 1339–44. doi:10.3892/ijo.24.5.1339. PMID 15067358.
  6. ^ "Entrez Gene: SNF1LK2 SNF1-like kinase 2".
  7. ^ Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M (May 2003). "Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2". The Journal of Biological Chemistry. 278 (20): 18440–7. doi:10.1074/jbc.M211770200. PMID 12624099.
  • Katoh M, Katoh M (Nov 2003). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats". International Journal of Oncology. 23 (5): 1471–6. doi:10.3892/ijo.23.5.1471. PMID 14532992.
  • Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
  • Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
  • Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M (Nov 2004). "Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm". European Journal of Biochemistry. 271 (21): 4307–19. doi:10.1111/j.1432-1033.2004.04372.x. PMID 15511237.
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Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
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IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
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Tropomyosin kinase (EC 2.7.11.28)
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
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Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
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