Pelubiprofen
Chemical compound
- Rx in several countries
- 2-[4-[(E)-(2-Oxocyclohexylidene)methyl]phenyl]propanoic acid
- 69956-77-0
- 5282203
- DB12150
- 1619C79FVJ
- DTXSID2048795
- Interactive image
- CC(C1=CC=C(C=C1)/C=C/2\CCCCC2=O)C(=O)O
InChI
- InChI=1S/C16H18O3/c1-11(16(18)19)13-8-6-12(7-9-13)10-14-4-2-3-5-15(14)17/h6-11H,2-5H2,1H3,(H,18,19)/b14-10+
- Key:AUZUGWXLBGZUPP-GXDHUFHOSA-N
Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis.[1]
Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia,[2] among other countries.
Research
Pelubiprofen is being studied for use in combination with eperisone.[3]
Because pelubiprofen has low water solubility, development of salt formulations with better solubility are being studied.[4]
References
- ^ "Pelubiprofen - Daewon Pharmaceutical". AdisInsight. Springer Nature Switzerland AG.
- ^ Chan-Hyuk K (26 September 2023). "Daewon Pharm wins $3 million deal to export Pelubi to Indonesia". Korea Biomedial Review.
- ^ "(Eperisone + pelubiprofen) by Daewon Pharmaceutical for Low Back Pain: Likelihood of Approval". pharmaceutical-technology.com. 5 June 2023.
- ^ Park JY, Oh DH, Park SW, Chae BR, Kim CW, Han SH, et al. (May 2021). "Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption". Pharmaceutics. 13 (5): 745. doi:10.3390/pharmaceutics13050745. PMC 8158122. PMID 34070062.
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pyrazolidines
and related substances
- Ampiroxicam
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derivatives (profens)
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- COX-inhibiting nitric oxide donator: Naproxcinod
acids (fenamates)
(coxibs)
combinations
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use.
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