NLRP7

Protein-coding gene in the species Homo sapiens

NLRP7

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
2KM6

Identifiers

Aliases

NLRP7, CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3, NLR family, pyrin domain containing 7, NLR family pyrin domain containing 7

External IDs

OMIM: 609661 HomoloGene: 51401 GeneCards: NLRP7

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.42	Start	54,923,509 bp^[1]
Band	19q13.42	End	54,966,312 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

blood

duodenum

appendix

lymph node

spleen

monocyte

placenta

rectum

bone marrow

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	ATP binding nucleotide binding aspartic-type endopeptidase inhibitor activity interleukin-1 binding caspase binding
Cellular component	cellular component
Biological process	negative regulation of endopeptidase activity negative regulation of protein processing cellular response to lipopolysaccharide cellular response to interleukin-1 negative regulation of cytokine production involved in inflammatory response negative regulation of aspartic-type peptidase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


199713


n/a

Ensembl

ENSG00000276804 ENSG00000167634 ENSG00000278173 ENSG00000277179 ENSG00000274174
ENSG00000277776 ENSG00000277786 ENSG00000275483 ENSG00000277071 ENSG00000274571


n/a

UniProt


Q8WX94


n/a

RefSeq (mRNA)


NM_001127255 NM_139176 NM_206828 NM_001405531


n/a

RefSeq (protein)


NP_001120727 NP_631915 NP_996611


n/a

Location (UCSC)

Chr 19: 54.92 – 54.97 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.^[3]^[4]^[5]

Function

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.^[5]

References

^ ^a ^b ^c ENSG00000167634, ENSG00000278173, ENSG00000277179, ENSG00000274174, ENSG00000277776, ENSG00000277786, ENSG00000275483, ENSG00000277071, ENSG00000274571 GRCh38: Ensembl release 89: ENSG00000276804, ENSG00000167634, ENSG00000278173, ENSG00000277179, ENSG00000274174, ENSG00000277776, ENSG00000277786, ENSG00000275483, ENSG00000277071, ENSG00000274571 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.
^ ^a ^b "Entrez Gene: NLRP7 NLR family, pyrin domain containing 7".