NLRP14

Protein-coding gene in the species Homo sapiens
NLRP14
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4N1J, 4N1K, 4N1L

Identifiers
AliasesNLRP14, CLR11.2, GC-LRR, NALP14, NOD5, PAN8, NLR family, pyrin domain containing 14, NLR family pyrin domain containing 14
External IDsOMIM: 609665; MGI: 1924108; HomoloGene: 18531; GeneCards: NLRP14; OMA:NLRP14 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NLRP14
Genomic location for NLRP14
Band11p15.4Start7,020,479 bp[1]
End7,071,526 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for NLRP14
Genomic location for NLRP14
Band7|7 E3Start106,766,197 bp[2]
End106,797,309 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • bone marrow cells

  • ganglionic eminence

  • liver

  • kidney

  • spinal cord

  • right uterine tube

  • rectum

  • ovary
Top expressed in
  • secondary oocyte

  • spermatid

  • spermatocyte

  • seminiferous tubule

  • morula

  • ovary

  • blastocyst

  • cumulus cell

  • islet of Langerhans

  • grey matter
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ATP binding
  • nucleotide binding
Cellular component
  • cytoplasm
Biological process
  • cell differentiation
  • multicellular organism development
  • spermatogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

338323

76858

Ensembl

ENSG00000158077

ENSMUSG00000016626

UniProt

Q86W24

Q6B966

RefSeq (mRNA)

NM_176822

NM_001002894

RefSeq (protein)

NP_789792

NP_001002894

Location (UCSC)Chr 11: 7.02 – 7.07 MbChr 7: 106.77 – 106.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.[5] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158077 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016626 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
  6. ^ Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801.

Further reading

  • Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
  • Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human NACHT, LRR and PYD domains-containing protein 14 (NLRP14)
  • v
  • t
  • e
CARD domain containing
Pyrin domain containingApoptosis inhibitory protein
  • NAIP
Family member X1


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