P2RY13

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Purinski receptor P2Y, G-protein spregnuti, 13
Identifikatori
SimboliP2RY13; GPCR1; FKSG77; GPR86; GPR94; P2Y13; SP174
Vanjski IDOMIM: 606380 MGI: 1921441 HomoloGene: 12543 IUPHAR: P2Y13 GeneCards: P2RY13 Gene
Ontologija gena
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez5382974191
EnsemblENSG00000181631ENSMUSG00000036362
UniProtQ9BPV8Q0VF10
RefSeq (mRNA)NM_023914NM_028808
RefSeq (protein)NP_076403NP_083084
Lokacija (UCSC)Chr 3:
152.53 - 152.53 Mb		Chr 3:
59.3 - 59.3 Mb
PubMed pretraga[1][2]

P2Y purinoceptor 13 je protein koji je kod ljudi kodiran P2RY13 genom.[1][2][3]

Proizvod ovog gena, P2Y13, je član familije G-protein spregnutih receptora. Ova familija ima nekoliko tipova receptora sa različitom farmakološkom selektivnosti za razne adenozinske i uridinske nukleotide. Oni se preklapaju u nekim slučajevima. Endogeni ligand ovog receptora je ADP. Dve transkriptne varijante koje kodiraju isti protein su poznate.[3]

Vidi još

  • P2Y receptor

Reference

  1. ↑ Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). „An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors”. J Mol Biol 307 (3): 799–813. DOI:10.1006/jmbi.2001.4520. PMID 11273702. 
  2. ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). „Discovery and mapping of ten novel G protein-coupled receptor genes”. Gene 275 (1): 83–91. DOI:10.1016/S0378-1119(01)00651-5. PMID 11574155. 
  3. ↑ 3,0 3,1 „Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13”. 

Literatura

  • Communi D, Gonzalez NS, Detheux M, et al. (2001). „Identification of a novel human ADP receptor coupled to G(i).”. J. Biol. Chem. 276 (44): 41479–85. DOI:10.1074/jbc.M105912200. PMID 11546776. 
  • Zhang FL, Luo L, Gustafson E, et al. (2002). „P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse.”. J. Pharmacol. Exp. Ther. 301 (2): 705–13. DOI:10.1124/jpet.301.2.705. PMID 11961076. 
  • Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

Spoljašnje veze

  • „P2Y Receptors: P2Y13”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)