GPR3

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G protein-spregnuti receptor 3
Identifikatori
SimboliGPR3; ACCA
Vanjski IDOMIM: 600241 MGI: 101908 HomoloGene: 31303 IUPHAR: GPR3 GeneCards: GPR3 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
Celularna komponenta • integralno sa ćelijskom membranom
• membrana
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
• G-protein signalizacija, put aktivacije adenilat ciklaze
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez282714748
EnsemblENSG00000181773ENSMUSG00000049649
UniProtP46089Q3USD4
RefSeq (mRNA)NM_005281NM_008154
RefSeq (protein)NP_005272NP_032180
Lokacija (UCSC)Chr 1:
27.59 - 27.59 Mb		Chr 4:
132.48 - 132.48 Mb
PubMed pretraga[1][2]

GPR3, G-protein spregnuti receptor 3, je protein koji je kod čoveka kodiran GPR3 genom.[1][2] Ovaj protein je transmembranski receptor koji učestvuje u prenosu signala.

Funkcija

GPR3 aktivira adenilat ciklazu u odsustvu liganda.[3] GPR3 je izražen u jajnim ćelijama sisara gde održava mejozno zadržavanje i smatra se da je komunikacioni link između jajnih ćelija i okružujućeg somatskog tkiva.[4] Bilo je predloženo da su sfingozin 1-fosfat (S1P) i sfingozilfosforilholin (SPC) GPR3 ligandi,[5][6], međutim ti rezultati nisu potvrđeni testom β-arestin regrutovanja.[7]

Literatura

  1. ↑ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). „Cloning of human genes encoding novel G protein-coupled receptors”. Genomics 23 (3): 609–18. DOI:10.1006/geno.1994.1549. PMID 7851889. 
  2. ↑ „Entrez Gene: GPR3 G protein-coupled receptor 3”. 
  3. ↑ Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F (August 1995). „Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase”. Biochem. J. 309 (Pt 3): 837–43. PMC 1135708. PMID 7639700. 
  4. ↑ Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA (December 2004). „The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes”. Science (journal) 306 (5703): 1947–50. DOI:10.1126/science.1103974. PMID 15591206. 
  5. ↑ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). „Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors”. Cell. Signal. 14 (11): 941–53. DOI:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
  6. ↑ Hinckley M, Vaccari S, Horner K, Chen R, Conti M (November 2005). „The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes”. Dev. Biol. 287 (2): 249–61. DOI:10.1016/j.ydbio.2005.08.019. PMID 16229830. 
  7. ↑ Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA (May 2009). „Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay”. J. Biol. Chem. 284 (18): 12328–38. DOI:10.1074/jbc.M806516200. PMC 2673301. PMID 19286662. 

Dodatna literatura

  • Eggerickx D, Denef JF, Labbe O, et al. (1995). „Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.”. Biochem. J. 309 (Pt 3): 837–43. PMC 1135708. PMID 7639700. 
  • Iismaa TP, Kiefer J, Liu ML, et al. (1995). „Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system.”. Genomics 24 (2): 391–4. DOI:10.1006/geno.1994.1635. PMID 7698767. 
  • Heiber M, Docherty JM, Shah G, et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25–35. DOI:10.1089/dna.1995.14.25. PMID 7832990. 
  • Song ZH, Modi W, Bonner TI (1996). „Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.”. Genomics 28 (2): 347–9. DOI:10.1006/geno.1995.1154. PMID 8530049. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Uhlenbrock K, Huber J, Ardati A, et al. (2003). „Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.”. Cell. Physiol. Biochem. 13 (2): 75–84. DOI:10.1159/000070251. PMID 12649592. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)