Sutezolid

Sutezolid
Names
Preferred IUPAC name
N-({(5S)-3-[3-Fluoro-4-(thiomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
Identifiers
CAS Number
  • 168828-58-8 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 409595
ECHA InfoCard 100.237.103 Edit this at Wikidata
KEGG
  • D10167
PubChem CID
  • 465951
UNII
  • 3A71182L8P checkY
CompTox Dashboard (EPA)
  • DTXSID20168611 Edit this at Wikidata
InChI
  • InChI=1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
    Key: FNDDDNOJWPQCBZ-ZDUSSCGKSA-N
  • InChI=1/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
    Key: FNDDDNOJWPQCBZ-ZDUSSCGKBM
  • CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(c(c2)F)N3CCSCC3
Properties
Chemical formula
C16H20FN3O3S
Molar mass 353.41 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

Sutezolid (PNU-100480, PF-02341272) is an oxazolidinone antibiotic currently in development as a treatment for extensively drug-resistant tuberculosis. It differs from linezolid by replacement of the morpholine oxygen with a sulfur atom.

Notes

  • Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide
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Antibacterials that inhibit protein synthesis (J01A, J01B, J01F, J01G, QJ01XQ)
30S
Aminoglycosides
(initiation inhibitors)
-mycin (Streptomyces)
-micin (Micromonospora)
other
Tetracycline antibiotics
(tRNA binding)
Tetracyclines
Glycylcyclines
50S
Oxazolidinone
(initiation inhibitors)
Peptidyl transferase
Amphenicols
Pleuromutilins
MLS (transpeptidation/translocation)
Macrolides
Ketolides
Lincosamides
Streptogramins
EF-G
Steroid antibacterials
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