Hydrocortamate

Chemical compound
Hydrocortamate
Clinical data
Trade namesMagnacort, Ulcort
Other names11β,17α-Dihydroxy-3,20-dioxopregn-4-en-21-yl N,N-diethylglycinate
Routes of
administration
Topical
Pharmacokinetic data
ExcretionHepatic
Identifiers
  • [2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,

    16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl]

    2-(diethylamino)acetate
CAS Number
  • 76-47-1
PubChem CID
  • 408334
PubChem SID
  • 46509076
DrugBank
  • DB00769
ChemSpider
  • 361312
UNII
  • Y3N00BK5WK
ChEBI
  • CHEBI:50851
ChEMBL
  • ChEMBL1201263
CompTox Dashboard (EPA)
  • DTXSID1057824 Edit this at Wikidata
ECHA InfoCard100.000.877 Edit this at Wikidata
Chemical and physical data
FormulaC27H41NO6
Molar mass475.626 g·mol−1
3D model (JSmol)
  • Interactive image
  • [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)COC(=O)CN(CC)CC
InChI
  • InChI=1S/C27H41NO6/c1-5-28(6-2)15-23(32)34-16-22(31)27(33)12-10-20-19-8-

    7-17-13-18(29)9-11-25(17,3)24(19)21(30)14-26(20,27)4/h13,19-21,24,30,

    33H,5-12,14-16H2,1-4H3
  • Key:FWFVLWGEFDIZMJ-UHFFFAOYSA-N

Hydrocortamate (brand names Magnacort, Ulcortis) is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties.[1][2] It is used topically to treat inflammation due to corticosteroid-responsive dermatoses.[3]

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 317–. ISBN 978-1-4757-2085-3.
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 524–. ISBN 978-3-88763-075-1.
  3. ^ DrugBank DB00769


  • v
  • t
  • e
Glucocorticoids
Natural
Synthetic
AntiglucocorticoidsSynthesis modifiers
See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
  • v
  • t
  • e
GRTooltip Glucocorticoid receptor
Agonists
  • Nonsteroidal glucocorticoids: AZD-5423
  • GSK-9027
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
  • Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids