CYP1A2

Cytochrome P450, family 1, subfamily A, polypeptide 2
PDB根据2hi4所绘制的渲染图
有效结构
PDB 直系同源检索：PDBe, RCSB
PDB查询代码列表

2HI4

标识
代号 CYP1A2; CP12; P3-450; P450(PA)
扩展标识 遗传学：124060 鼠基因：88589 同源基因：68082 ChEMBL: 3356 GeneCards: CYP1A2 Gene
EC編號 1.14.14.1
基因本体论描述
分子功能 · monooxygenase activity

· iron ion binding
· electron carrier activity
· oxidoreductase activity
· oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
· enzyme binding
· heme binding
· demethylase activity
· caffeine oxidase activity

· aromatase activity
细胞成分 · endoplasmic reticulum membrane
· intracellular membrane-bounded organelle
生物过程 · steroid catabolic process

· porphyrin-containing compound metabolic process
· xenobiotic metabolic process
· toxin biosynthetic process
· post-embryonic development
· alkaloid metabolic process
· regulation of gene expression
· monoterpenoid metabolic process
· drug metabolic process
· dibenzo-p-dioxin metabolic process
· arachidonic acid metabolic process
· epoxygenase P450 pathway
· lung development
· methylation
· response to estradiol
· response to lipopolysaccharide
· monocarboxylic acid metabolic process
· response to immobilization stress
· drug catabolic process
· exogenous drug catabolic process
· small molecule metabolic process
· cellular respiration
· heterocycle metabolic process
· hydrogen peroxide biosynthetic process
· oxidation-reduction process
· oxidative demethylation
· cellular response to cadmium ion
· oxidative deethylation

· omega-hydroxylase P450 pathway
Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 1544 13077
Ensembl ENSG00000140505 ENSMUSG00000032310
UniProt P05177 P00186
mRNA序列 NM_000761 NM_009993
蛋白序列 NP_000752 NP_034123
基因位置 Chr 15:
74.75 – 74.76 Mb		 Chr 9:
57.68 – 57.68 Mb
PubMed查询 [1] [2]
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细胞色素P450 1A2（英語：Cytochrome P450 1A2） （缩写为CYP1A2），是细胞色素P450混合功能氧化酶家族的一员，参与体内异生物质的代谢。[1]CYP1A2酶由人类CYP1A2基因编码。[2]

引用

  1. ^ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. January 2004, 14 (1): 1–18. PMID 15128046. doi:10.1097/00008571-200401000-00001. 
  2. ^ Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ. Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15. J. Exp. Pathol. 1987, 3 (1): 1–17. PMID 3681487. 

延伸閱讀

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  • Landi MT, Sinha R, Lang NP, Kadlubar FF. Human cytochrome P4501A2.. IARC Sci. Publ. 1999, (148): 173–95. PMID 10493258. 
  • Ikeya K, Jaiswal AK, Owens RA; et al. Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.. Mol. Endocrinol. 1990, 3 (9): 1399–408. PMID 2575218. doi:10.1210/mend-3-9-1399. 
  • Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.. Proc. Natl. Acad. Sci. U.S.A. 1989, 86 (20): 7696–700. PMC 298137 可免费查阅. PMID 2813353. doi:10.1073/pnas.86.20.7696. 
  • Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH. Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.. DNA. 1986, 4 (5): 395–400. PMID 3000715. doi:10.1089/dna.1985.4.395. 
  • Quattrochi LC, Pendurthi UR, Okino ST; et al. Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.. Proc. Natl. Acad. Sci. U.S.A. 1986, 83 (18): 6731–5. PMC 386583 可免费查阅. PMID 3462722. doi:10.1073/pnas.83.18.6731. 
  • Wrighton SA, Campanile C, Thomas PE; et al. Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.. Mol. Pharmacol. 1986, 29 (4): 405–10. PMID 3517618. 
  • Jaiswal AK, Nebert DW, Gonzalez FJ. Human P3(450): cDNA and complete amino acid sequence.. Nucleic Acids Res. 1986, 14 (16): 6773–4. PMC 311685 可免费查阅. PMID 3755823. doi:10.1093/nar/14.16.6773. 
  • Eugster HP, Probst M, Würgler FE, Sengstag C. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.. Drug Metab. Dispos. 1993, 21 (1): 43–9. PMID 8095225. 
  • Schweikl H, Taylor JA, Kitareewan S; et al. Expression of CYP1A1 and CYP1A2 genes in human liver.. Pharmacogenetics. 1994, 3 (5): 239–49. PMID 8287062. doi:10.1097/00008571-199310000-00003. 
  • Yamazaki H, Inoue K, Mimura M; et al. 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.. Biochem. Pharmacol. 1996, 51 (3): 313–9. PMID 8573198. doi:10.1016/0006-2952(95)02178-7. 
  • Hakkola J, Raunio H, Purkunen R; et al. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.. Biochem. Pharmacol. 1996, 52 (2): 379–83. PMID 8694864. doi:10.1016/0006-2952(96)00216-X. 
  • Guengerich FP, Johnson WW. Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.. Biochemistry. 1998, 36 (48): 14741–50. PMID 9398194. doi:10.1021/bi9719399. 
  • Wacke R, Kirchner A, Prall F; et al. Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.. Pancreas. 1998, 16 (4): 521–8. PMID 9598815. doi:10.1097/00006676-199805000-00011. 
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  • Huang JD, Guo WC, Lai MD; et al. Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.. Drug Metab. Dispos. 1999, 27 (1): 98–101. PMID 9884316. 
  • Tatemichi M, Nomura S, Ogura T; et al. Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.. Cancer Res. 1999, 59 (16): 3893–8. PMID 10463577.