| NR1H4 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8 | | |
| Ідентифікатори |
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| Символи | NR1H4, BAR, FXR, HRR-1, HRR1, RIP14, nuclear receptor subfamily 1 group H member 4, PFIC5 |
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| Зовнішні ІД | OMIM: 603826 MGI: 1352464 HomoloGene: 3760 GeneCards: NR1H4 |
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| Реагує на сполуку |
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| chenodiol, fexaramine, obeticholic acid, (E)-guggulsterone[1] |
| nidufexor[2] |
| Онтологія гена |
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| Молекулярна функція | • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific DNA binding
• DNA binding
• GO:0001106 transcription corepressor activity
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001105 transcription coactivator activity
• zinc ion binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• зв'язування з іоном металу
• retinoid X receptor binding
• steroid hormone receptor activity
• bile acid binding
• GO:0001948, GO:0016582 protein binding
• nuclear receptor binding
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
• chenodeoxycholic acid binding
• GO:0000975 transcription cis-regulatory region binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
• bile acid receptor activity
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• transcription factor binding
• nuclear receptor coactivator activity
• signaling receptor activity
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| Клітинна компонента | • нуклеоплазма
• клітинне ядро
• RNA polymerase II transcription regulator complex
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| Біологічний процес | • Сигнальний шлях Notch
• cellular triglyceride homeostasis
• cellular response to organonitrogen compound
• regulation of insulin secretion involved in cellular response to glucose stimulus
• positive regulation of ammonia assimilation cycle
• toll-like receptor 4 signaling pathway
• процес імунної системи
• histone H3-R17 methylation
• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
• positive regulation of glutamate metabolic process
• intracellular bile acid receptor signaling pathway
• negative regulation of apoptotic process
• GO:1901227 negative regulation of transcription by RNA polymerase II
• transcription, DNA-templated
• regulation of low-density lipoprotein particle clearance
• regulation of bile acid biosynthetic process
• regulation of cholesterol metabolic process
• regulation of urea metabolic process
• intracellular receptor signaling pathway
• negative regulation of bile acid biosynthetic process
• cellular response to fatty acid
• bile acid and bile salt transport
• nitrogen catabolite activation of transcription from RNA polymerase II promoter
• transcription initiation from RNA polymerase II promoter
• inflammatory response
• вроджений імунітет
• GO:0072468 сигнальна трансдукція
• steroid hormone mediated signaling pathway
• fatty acid homeostasis
• GO:1903106 positive regulation of insulin receptor signaling pathway
• cellular response to lipopolysaccharide
• negative regulation of interleukin-2 production
• positive regulation of insulin secretion involved in cellular response to glucose stimulus
• negative regulation of inflammatory response
• glucose homeostasis
• negative regulation of NF-kappaB transcription factor activity
• positive regulation of adipose tissue development
• cell-cell junction assembly
• toll-like receptor 9 signaling pathway
• negative regulation of monocyte chemotactic protein-1 production
• bile acid metabolic process
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• negative regulation of tumor necrosis factor-mediated signaling pathway
• defense response to bacterium
• negative regulation of interleukin-1 production
• negative regulation of tumor necrosis factor production
• negative regulation of interleukin-6 production
• triglyceride homeostasis
• negative regulation of interferon-gamma production
• GO:0009373 regulation of transcription, DNA-templated
• bile acid signaling pathway
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• positive regulation of phosphatidic acid biosynthetic process
• cholesterol homeostasis
• lipid metabolism
• multicellular organism development
• диференціація клітин
• lipid homeostasis
• cellular glucose homeostasis
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | NM_001206977
NM_001206978
NM_001206979
NM_001206992
NM_001206993
| | NM_005123 |
| | NM_001163504
NM_001163700
NM_009108
NM_001385711 |
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| RefSeq (білок) | NP_001193906
NP_001193907
NP_001193908
NP_001193921
NP_001193922
| NP_005114
NP_001193906.1
NP_001193908.1 |
| | NP_001156976
NP_001157172
NP_033134
NP_001372640 |
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| Локус (UCSC) | Хр. 12: 100.47 – 100.56 Mb | Хр. 10: 89.29 – 89.37 Mb |
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| PubMed search | [3] | [4] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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