CCL19

Hemokin (C-C motiv) ligand 19

Identifikatori

CCL19; CKb11; ELC; MGC34433; MIP-3b; MIP3B; SCYA19

Vanjski ID

OMIM: 602227 MGI: 1346316 HomoloGene: 4569 GeneCards: CCL19 Gene

Ontologija gena
Molekularna funkcija	• hemokinska aktivnost
Celularna komponenta	• ekstracelularni region • ekstracelularni prostor
Biološki proces	• celularna homeostaza kalcijum jona • hemotaksa • inflamatorni odgovor • imunski odgovor • transdukcija signala • respons na viruse

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

6363

24047

Ensembl

ENSG00000172724

n/a

UniProt

Q99731

n/a

RefSeq (mRNA)

NM_006274

NM_011888

RefSeq (protein)

NP_006265

NP_036018

Lokacija (UCSC)

Chr 9:
34.68 - 34.68 Mb

n/a

PubMed pretraga

[1]

[2]

CCL19, hemokin (C-C motiv) ligand 19, je protein koji je kod ljudi kodiran CCL19 genom.^[1]^[2] CCL19 ja mali citokin iz CC hemokin familije koji je takođe poznat kao EBI1 ligand hemokin (ELC) i makrofagni inflamatorni protein-3-beta (MIP-3-beta).^[3]

Ovaj gen je jedan od nekoliko CC citokinskih gena grupisanih na p-ruci hromozoma 9^[4] Ovaj hemokin dejstvuje na svoje ciljne ćelije vezivanjem za hemokinski receptor CCR7.^[5]. Citokini su familija izlučenih proteina koji učestvuju u imunoregulatornim i inflamatornim procesima. CC citokini su proteini karakterisani sa dva susedna cisteina. Za citokin kodiran ovim genom se veruje da igra ulogu u normalnoj recirkulaciji limfocita. On takođe ima važnu ulogu u razmeni T ćelija u timusu, i u migraciji T ćelija i B ćelija u sekundarne limfoidne organe. On se specifično vezuje za hemokinski receptor CCR7.^[2]

CCL19 je obilno izražen u timusu i limfnim čvorovima, u umerenim nivoima u traheji i kolonu, i u niskim nivoima u stomaku, tankim crevima, plućima, bubrezima i slezini.^[5] On privlači određene ćelije imunskog sistema, kao što su dendritske ćelije i antigen-aktivirane B ćelije,^[6]^[7] CCR7+ efektorske-memorijske T-ćelije.^[8]

Reference

^ Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). „Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7”. J Biol Chem. 272 (21): 13803—9. PMID 9153236. doi:10.1074/jbc.272.21.13803.
^ ^а ^б „Entrez Gene: CCL19 chemokine (C-C motif) ligand 19”.
^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
^ Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). „Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta”. J. Immunol. 158 (3): 1033—6. PMID 9013939.
^ ^а ^б Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). „Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7”. J. Biol. Chem. 272 (21): 13803—9. PMID 9153236. doi:10.1074/jbc.272.21.13803.
^ Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). „The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes”. Cell. 103 (5): 757—68. PMID 11114332. doi:10.1016/S0092-8674(00)00179-3.
^ Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). „Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position”. Nature. 416 (6876): 94—9. PMID 11882900. doi:10.1038/416094a.
^ Bromley SK, Thomas SY, Luster AD (2005). „Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics”. Nat. Immunol. 6 (9): 895—901. PMID 16116469. doi:10.1038/ni1240.

Literatura

Dodatna literatura

Weber C, Koenen RR (2006). „Fine-tuning leukocyte responses: towards a chemokine 'interactome'.”. Trends Immunol. 27 (6): 268—73. PMID 16678487. doi:10.1016/j.it.2006.04.002.
Rossi DL; Vicari AP; Franz-Bacon K; et al. (1997). „Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.”. J. Immunol. 158 (3): 1033—6. PMID 9013939.
Nagira M; Imai T; Hieshima K; et al. (1997). „Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13.”. J. Biol. Chem. 272 (31): 19518—24. PMID 9235955. doi:10.1074/jbc.272.31.19518.
Kim CH; Pelus LM; White JR; et al. (1998). „CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.”. J. Immunol. 160 (5): 2418—24. PMID 9498785.
Yanagihara S; Komura E; Nagafune J; et al. (1998). „EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation.”. J. Immunol. 161 (6): 3096—102. PMID 9743376.
Gosling J; Dairaghi DJ; Wang Y; et al. (2000). „Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.”. J. Immunol. 164 (6): 2851—6. PMID 10706668.
Annunziato F; Romagnani P; Cosmi L; et al. (2000). „Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection.”. J. Immunol. 165 (1): 238—46. PMID 10861057.
Ueno T; Hara K; Willis MS; et al. (2002). „Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.”. Immunity. 16 (2): 205—18. PMID 11869682. doi:10.1016/S1074-7613(02)00267-4.
Phillips R, Ager A (2002). „Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells.”. Eur. J. Immunol. 32 (3): 837—47. PMID 11870628. doi:10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q.
Till KJ, Lin K, Zuzel M, Cawley JC (2002). „The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.”. Blood. 99 (8): 2977—84. PMID 11929789. doi:10.1182/blood.V99.8.2977.
Townson JR, Nibbs RJ (2002). „Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.”. Eur. J. Immunol. 32 (5): 1230—41. PMID 11981810. doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L.
Page G, Lebecque S, Miossec P (2002). „Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium.”. J. Immunol. 168 (10): 5333—41. PMID 11994492.
Katou F; Ohtani H; Nakayama T; et al. (2003). „Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin.”. J. Pathol. 199 (1): 98—106. PMID 12474232. doi:10.1002/path.1255.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Scandella E; Men Y; Legler DF; et al. (2004). „CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2.”. Blood. 103 (5): 1595—601. PMID 14592837. doi:10.1182/blood-2003-05-1643.
Corcione A; Arduino N; Ferretti E; et al. (2004). „CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells.”. Clin. Cancer Res. 10 (3): 964—71. PMID 14871974. doi:10.1158/1078-0432.CCR-1182-3.
Daikoku N; Kitaya K; Nakayama T; et al. (2004). „Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle.”. Fertil. Steril. 81 Suppl 1: 876—81. PMID 15019823. doi:10.1016/j.fertnstert.2003.09.036.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Paoletti S; Petkovic V; Sebastiani S; et al. (2005). „A rich chemokine environment strongly enhances leukocyte migration and activities.”. Blood. 105 (9): 3405—12. PMID 15546958. doi:10.1182/blood-2004-04-1648.

Spoljašnje veze

CCL19 GeneCard

Ćelijska komunikacija: Citokini

Po familiji

Interleukin

IL-1 superfamilija	1 (1Ra) 18 33
poput IL-6/gp130 koristeći	6 11 27 30 31 (+ne IL Onkostatin M Inhibitorni faktor leukemije Cilijarni neurotrofni faktor Kardiotrofin 1)
IL-10 familija	10 19 20 22 24 26
Interferon tip III	28 29
Zajednički γ-lanac familija	2/15 3 4 7 9 13 21
IL-12 familija	12 (B) 23 27 35
Drugi	5 8 14 16 17/25 (A) 32 34

Hemokini

CCL	1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
CXCL	1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
CX3CL	1
XCL	1 2

TNF

Glavni	TNF-alfa
TNF (ligand) superfamilija	4-1BB ligand Faktor aktivacije B-ćelija FAS ligand Limfotoksin OX40L RANKL TRAIL
Klaster diferencijacije	CD70 CD153 CD154