Guanoksan

Guanoksan
Klinički podaci
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 2165-19-7
ATC kod C02CC03
PubChem[1][2] 16564
UNII 9V0MRL0R5Y DaY
Hemijski podaci
Formula C10H13N3O2 
Mol. masa 207,229
SMILES eMolekuli & PubHem
InChI
InChI=1S/C10H13N3O2/c11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7/h1-4,7H,5-6H2,(H4,11,12,13)
Key: HIUVKVDQFXDZHU-UHFFFAOYSA-N DaY
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Guanoksan je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 207,229 Da.

Osobine

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 2
Broj rotacionih veza 2
Particioni koeficijent[3] (ALogP) 0,7
Rastvorljivost[4] (logS, log(mol/L)) -1,7
Polarna površina[5] (PSA, Å2) 82,9

Reference

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o. 
  4. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573. 
  5. Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286. 

Literatura

  • Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7. 
  • Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9. 

Spoljašnje veze

Portal Medicina
Portal Hemija
Guanoksan na Wikimedijinoj ostavi
  • Guanoxan
  • p
  • r
  • u
Simpatolitici
(antagoniziraju α-adrenergičku
vazokonstrikciju)
Centralni
α2 agonist
Inhibitori otpuštanja adrenalina
Periferalni
Indirektni
Direktni
α1 blokatori
Neselektivni α blokator
Drugi antagonisti
dualni (Bosentan) * selektivni (Ambrisentan, Sitaksentan)

M: VAS

anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

vabo/siva/kong/tumr, sizn/epon

proc, lek (C2s+n/3/4/5/7/8/9)