Glutation transferaza
| Glutation transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.5.1.18 | ||||||||
| CAS broj | 50812-37-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glutation transferaza (EC 2.5.1.18, glutation S-transferaza, glutation S-alkiltransferaza, glutation S-ariltransferaza, S-(hidroksialkil)glutation lijaza, glutation S-aralkiltransferaza, glutation S-alkil transferaza, GST) je enzim sa sistematskim imenom RX:glutation R-transferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- RX + glutation HX + R-S-glutation
Ova grupa enzima ima široku specifičnost. R može da bude alifatična, aromatična ili heterociklična grupa; X može da bude sulfatna, nitrilna ili halidna grupa.
Reference
- ↑ Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1974). „Glutathione S-transferases. The first enzymatic step in mercapturic acid formation”. J. Biol. Chem. 249: 7130-7139. PMID 4436300.
- ↑ Jakoby, W.B. (1978). „The glutathione S-transferases: a group of multifunctional detoxification proteins”. Adv. Enzymol. Relat. Areas Mol. Biol. 46: 383-383. PMID 345769.
- ↑ Jakoby, W.B. (1985). „Glutathione transferases: an overview”. Methods Enzymol. 113: 495-499. PMID 4088070.
- ↑ Keen, J.H. and Jakoby, W.B. (1978). „Glutathione transferases. Catalysis of nucleophilic reactions of glutathione”. J. Biol. Chem. 253: 5654-5657. PMID 670218.
- ↑ Sheehan, D., Meade, G., Foley, V.M. and Dowd, C.A. (2001). „Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily”. Biochem. J. 360: 1-16. PMID 11695986.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Glutathione+transferase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
