G protein spregnuti receptor kinaza

G protein spregnuti receptor kinaza
Identifikatori
EC broj 2.7.11.16
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G protein spregnuti receptor kinaze (GRK, GPCRK) su familija proteinskih kinaza koje regulišu aktivnost G protein-spregnutih receptora putem fosforilacije njihovih intracelularnih domena, nakon što se njihovi vezani G proteini odvojeni i aktivirani.

Fosforilisani ostaci serina i treonina dejstvuju kao mesta vezivanja proteina arestina, koji sprečavaju ponovno vezivanje G proteina sa njihovim receptorima. Na taj način oni sprečavaju reaktivaciju signalnog puta.[1]

GRK tipovi

Ime Napomene Gen OMIM
G protein spregnuti receptor kinaza 1 Rodopsinska kinaza GRK1 180381
G protein spregnuti receptor kinaza 2 β-Adrenergički receptor kinaza1 (BARK1) ADRBK1 (GRK2) 109635
G protein spregnuti receptor kinaza 3 β-Adrenergički receptor kinaza 2 (BARK2) ADRBK2 (GRK3) 109636
G protein spregnuti receptor kinaza 4 Smatra se da učestvuje u regulacionim funkcijama tubula bugrega GRK4 137026
G protein spregnuti receptor kinaza 5 Nokaut miševi imaju izmenjenu normalnu temperaturu tela GRK5 600870
G protein spregnuti receptor kinaza 6 Nokaut miševi su izuzetno senzitivni na dopaminergike[2] GRK6 600869
G protein spregnuti receptor kinaza 7 Opsinska kinaza GRK7 606987

Vidi još

Reference

  1. ↑ Ribas C, Penela P, Murga C, Salcedo A, García-Hoz C, Jurado-Pueyo M, Aymerich I, Mayor F (April 2007). „The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling”. Biochimica et Biophysica Acta 1768 (4): 913–22. DOI:10.1016/j.bbamem.2006.09.019. PMID 17084806. 
  2. ↑ Gainetdinov RR, Bohn LM, Sotnikova TD, et al. (April 2003). „Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice”. Neuron 38 (2): 291–303. DOI:10.1016/S0896-6273(03)00192-2. PMID 12718862. Pristupljeno 2009-08-14. 

Literatura

  • Sobierajska K, Fabczak H, Fabczak S (2005). „Mechanisms of Regulation and Function of G Protein-Coupled Receptor Kinases]” (Polish). Postepy Biochemii 51 (4): 421–9. PMID 16676577. 
  • Ma L, Gao J, Chen X (2005). „G Protein-Coupled Receptor Kinases”. u: Devi LA. The G Protein-Coupled Receptors Handbook (Contemporary Clinical Neuroscience). Totowa, NJ: Humana Press. 
  • Kurose H (2000). „G Protein-Coupled Kinases and Desensitization of Receptors”. u: Bernstein G, Tatsuya H. G protein-coupled receptors. Boca Raton: CRC Press. 
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(1) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.1-EC 2.7.11.20)
Nespecifična serin/treonin proteinske kinaze (EC 2.7.11.1)
LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Proteinska kinaza B (AKT1, AKT2, AKT3), Ataksija telangiektazija mutirani, Sisarski cilj rapamicina, EIF-2 kinaze (PKR, HRI), Wee1 (WEE1)
Piruvat dehidrogenazna kinaza (EC 2.7.11.2)
Defosfo-(reduktaza kinaza) kinaza (EC 2.7.11.3)
(3-metil-2-oksobutanoat dehidrogenaza (prenos acetila)) (EC 2.7.11.4)
BCKDK, BCKDHA, BCKDHB
(izocitrat dehidrogenaza (NADP+)) kinaza (EC 2.7.11.5)
IDH2, IDH3A, IDH3B, IDH3G
tirozin 3-monooksigenazna kinaza (EC 2.7.11.6)
Miozin-teški-lanac kinaza (EC 2.7.11.7)
Aurora kinaza (Aurora A kinaza, Aurora B kinaza)
Goodpasture-antigen-vezujuća proteinska kinaza (EC 2.7.11.9)
-
IκB kinaza (EC 2.7.11.10)
CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP
Proteinska kinaza A, PRKACG, PRKACB, PRKACA, PRKY
Protein kinaza C (EC 2.7.11.13)
Protein kinaza C, Protein kinaza Cζ, PKC alfa, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Proteinska zavisna proteinska N1, PKN2, PKN3,
Rodopsinska kinaza (EC 2.7.11.14)
Beta adrenergički receptor kinaza (EC 2.7.11.15)
Beta adrenergički receptor kinaza, Beta adrenergički receptor kinaza-2
G protein spregnuti receptor kinaza (EC 2.7.11.16)
Ca2+/kalmodulin-zavisna (EC 2.7.11.17)
BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1
MYLK, MYLK2, MYLK3, MYLK4
Fosforilazna kinaza (EC 2.7.11.19)
PHKA1, PHKA2, PHKB, PHKG1, PHKG2
Faktor elongacije 2 kinaza (EC 2.7.11.20)
Polo kinaza (EC 2.7.11.21)
PLK1, PLK2, PLK3, PLK4
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(2) Serin/treonin-specifične proteinske kinaze (EC 2.7.11.21-EC 2.7.11.30)
Polo kinaza (EC 2.7.11.21)
PLK1, PLK2, PLK3, PLK4
Ciklin-zavisna kinaza (EC 2.7.11.22)
CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1
(RNK-polimerazna)-podjedinica kinaza (EC 2.7.11.23)
RPS6KA5, RPS6KA4, P70S6 kinaza, P70-S6 kinaza 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1
Ekstracelularnim signalom regulisane (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogenom-aktivirani protein (MAPK11, MAPK13, MAPK14)
MAP3K (EC 2.7.11.25)
MAP kinaza kinaza kinaze (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLK (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14
Tau-proteinska kinaza (EC 2.7.11.26)
TPK1, TTK, GSK-3
acetil-CoA karboksilazna kinaza] (EC 2.7.11.27)
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Tropomiozinska kinaza (EC 2.7.11.28)
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Receptor lipoproteina-niske-gustine kinaza (EC 2.7.11.29)
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Receptor protein serin/treonin kinaza (EC 2.7.11.30)
Koštani morfogenetski proteinski receptori (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Mulerianski hormonski receptor
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(3) Kinaze dualne-specifičnosti (EC 2.7.12)
MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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Teme
Tipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6