GNAQ
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| Guanin nukleotid-vezujući protein (G protein), q polipeptid | |||||||||||
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 PDB prikaz baziran na 2bcj. | |||||||||||
| Dostupne strukture | |||||||||||
| 2bcj | |||||||||||
| Identifikatori | |||||||||||
| Simboli | GNAQ; G-ALPHA-q; GAQ | ||||||||||
| Vanjski ID | OMIM: 600998 MGI: 95776 HomoloGene: 1566 GeneCards: GNAQ Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2776 | 14682 | |||||||||
| Ensembl | ENSG00000156052 | ENSMUSG00000024639 | |||||||||
| UniProt | P50148 | Q3UHH5 | |||||||||
| RefSeq (mRNA) | NM_002072 | NM_008139 | |||||||||
| RefSeq (protein) | NP_002063 | NP_032165 | |||||||||
| Lokacija (UCSC) | Chr 9: 79.52 - 79.84 Mb | Chr 19: 16.2 - 16.45 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GNAQ, Guanin nukleotid-vezujući protein G(q), podjedinica alfa, je protein koji je kod ljudi kodiran GNAQ genom.[1]
Guanin nukleotid-vezujući proteini su familija heterotrimernih proteina koji se uparuju sa proteinima ćelijske površine, 7-TM domenskim receptorima, i posreduju intracelularnu signalizaciju. Aktivacija receptora katalizuje izmenu GDP za GTP. GDP je vezan za neaktivnu G protein alfa podedinicu. Vezivanje agonista dovodi do konformacione promene i disocijacije kompleksa. G protein alfa i beta-gama podjedinice imaju sposobnost regulacije niza celularnih efektora. Aktivacija se okončava GTPazom specifičnom za G-alfa podjedinicu. G-alfa-q podjedinica je jedan od heterotrimernih GTP-vezujućih proteina koji posreduje stimulaciju fosfolipaze C-beta (MIM 600230).[2]
Interakcije
Za GNAQ je bilo pokazano da interaguje sa natrijum-vodonik antiporterom 3, regulator 1,[3] RIC8A,[4][5] RGS16,[6] beta adrenergički receptor kinazom,[7] RGS4[6][8] i Brutonovom tirozinskom kinazom.[9]
Reference
- ↑ Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J (Feb 1997). „Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene”. Genomics 30 (3): 470–75. DOI:10.1006/geno.1995.1267. PMID 8825633.
- ↑ „Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide”.
- ↑ Rochdi, Moulay Driss; Watier Valérie, La Madeleine Carole, Nakata Hiroko, Kozasa Tohru, Parent Jean-Luc (October 2002). „Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)”. J. Biol. Chem. (United States) 277 (43): 40751–9. DOI:10.1074/jbc.M207910200. ISSN 0021-9258. PMID 12193606.
- ↑ Klattenhoff, Carla; Montecino Martín, Soto Ximena, Guzmán Leonardo, Romo Ximena, García María Angeles, Mellstrom Britt, Naranjo José Ramón, Hinrichs María Victoria, Olate Juan (May 2003). „Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol”. J. Cell. Physiol. (United States) 195 (2): 151–7. DOI:10.1002/jcp.10300. ISSN 0021-9541. PMID 12652642.
- ↑ Tall, Gregory G; Krumins Andrejs M, Gilman Alfred G (March 2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. (United States) 278 (10): 8356–62. DOI:10.1074/jbc.M211862200. ISSN 0021-9258. PMID 12509430.
- ↑ 6,0 6,1
- ↑ Day, Peter W; Carman Christopher V, Sterne-Marr Rachel, Benovic Jeffrey L, Wedegaertner Philip B (August 2003). „Differential interaction of GRK2 with members of the G alpha q family”. Biochemistry (United States) 42 (30): 9176–84. DOI:10.1021/bi034442. ISSN 0006-2960. PMID 12885252.
- ↑ Druey, K M; Sullivan B M, Brown D, Fischer E R, Watson N, Blumer K J, Gerfen C R, Scheschonka A, Kehrl J H (July 1998). „Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane”. J. Biol. Chem. (UNITED STATES) 273 (29): 18405–10. DOI:10.1074/jbc.273.29.18405. ISSN 0021-9258. PMID 9660808.
- ↑ Ma, Y C; Huang X Y (October 1998). „Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (21): 12197–201. DOI:10.1073/pnas.95.21.12197. ISSN 0027-8424. PMC 22808. PMID 9770463.
Literatura
- Raymond JR, Mukhin YV, Gelasco A, et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2-3): 179–212. DOI:10.1016/S0163-7258(01)00169-3. PMID 11916537.
- Van Oekelen D, Luyten WH, Leysen JE (2003). „5-HT2A and 5-HT2C receptors and their atypical regulation properties.”. Life Sci. 72 (22): 2429–49. DOI:10.1016/S0024-3205(03)00141-3. PMID 12650852.
- Lesch KP, Manji HK (1992). „Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain.”. Biol. Psychiatry 32 (7): 549–79. DOI:10.1016/0006-3223(92)90070-G. PMID 1333286.
- Thomas CP, Dunn MJ, Mattera R (1996). „Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.”. Biochem. J. 312 ( Pt 1): 151–8. PMC 1136238. PMID 7492305.
- Blin N, Yun J, Wess J (1995). „Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor.”. J. Biol. Chem. 270 (30): 17741–8. DOI:10.1074/jbc.270.30.17741. PMID 7629074.
- Kabouridis PS, Waters ST, Escobar S, et al. (1995). „Expression of GTP-binding protein alpha subunits in human thymocytes.”. Mol. Cell. Biochem. 144 (1): 45–51. DOI:10.1007/BF00926739. PMID 7791744.
- Allgeier A, Offermanns S, Van Sande J, et al. (1994). „The human thyrotropin receptor activates G-proteins Gs and Gq/11.”. J. Biol. Chem. 269 (19): 13733–5. PMID 8188646.
- Wedegaertner PB, Chu DH, Wilson PT, et al. (1993). „Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.”. J. Biol. Chem. 268 (33): 25001–8. PMID 8227063.
- Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). „Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.”. Endocrinology 132 (6): 2484–90. DOI:10.1210/en.132.6.2484. PMID 8504751.
- Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. DOI:10.1073/pnas.93.1.116. PMC 40189. PMID 8552586.
- Denker SP, McCaffery JM, Palade GE, et al. (1996). „Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas.”. J. Cell Biol. 133 (5): 1027–40. DOI:10.1083/jcb.133.5.1027. PMC 2120853. PMID 8655576.
- Chen B, Leverette RD, Schwinn DA, Kwatra MM (1996). „Human G(alpha q): cDNA and tissue distribution.”. Biochim. Biophys. Acta 1281 (2): 125–8. DOI:10.1016/0005-2736(96)00039-9. PMID 8664309.
- Johnson GJ, Leis LA, Dunlop PC (1996). „Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.”. Biochem. J. 318 ( Pt 3): 1023–31. PMC 1217719. PMID 8836152.
- Gomeza J, Mary S, Brabet I, et al. (1996). „Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.”. Mol. Pharmacol. 50 (4): 923–30. PMID 8863838.
- Petit A, Geoffroy P, Bélisle S (1997). „Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta.”. J. Soc. Gynecol. Investig. 3 (6): 316–21. DOI:10.1016/S1071-5576(96)00035-4. PMID 8923415.
- Petit A, Geoffroy P, Bélisle S (1997). „Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension.”. Life Sci. 60 (12): 953–60. DOI:10.1016/S0024-3205(96)00654-6. PMID 9061052.
- Kinsella BT, O'Mahony DJ, Fitzgerald GA (1997). „The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.”. J. Pharmacol. Exp. Ther. 281 (2): 957–64. PMID 9152406.
- Wise A, Parenti M, Milligan G (1997). „Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.”. FEBS Lett. 407 (3): 257–60. DOI:10.1016/S0014-5793(97)00300-1. PMID 9175863.
- Gabbeta J, Yang X, Kowalska MA, et al. (1997). „Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses.”. Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8750–5. DOI:10.1073/pnas.94.16.8750. PMC 23110. PMID 9238049.
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