Adenin fosforiboziltransferaza
| Adenin fosforiboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.4.2.7 | ||||||||
| CAS broj | 9027-80-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Adenin fosforiboziltransferaza (EC 2.4.2.7, AMP pirofosforilaza, transfosforibozidaza, APRT, AMP-pirofosfat fosforiboziltransferaza, adenin fosforibozilpirofosfat transferaza, adenozin fosforiboziltransferaza, adenilat pirofosforilaza, adenilinska pirofosforilaza) je enzim sa sistematskim imenom AMP:difosfat fosfo-D-riboziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- AMP + difosfat adenin + 5-fosfo-alfa-D-riboza 1-difosfat
5-Amino-4-imidazolekarboksamid može da zameni adenin.
Reference
- ↑ Flaks, J.G., Erwin, M.J. and Buchanan, J.M. (1957). „Biosynthesis of the purines. XVI. The synthesis of adenosine 5′-phosphate and 5-amino-4-imidazolecarboxamide ribotide by a nucleotide pyrophosphorylase”. J. Biol. Chem. 228: 201-213. PMID 13475309.
- ↑ Kornberg, A., Lieberman, I. and Simms, E.S. (1955). „Enzymatic synthesis of purine nucleotides”. J. Biol. Chem. 215: 417-427. PMID 14392175.
- ↑ Lukens, L.N. and Herrington, K.A. (1957). „Enzymic formation of 6-mercaptopurine ribotide”. Biochim. Biophys. Acta 24: 432-433. PMID 13436452.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Vanjske veze
- MeSH Adenine+phosphoribosyltransferase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
