ZHX2

Protein-coding gene in the species Homo sapiens
ZHX2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DMP, 3NAU

Identifiers
AliasesZHX2, AFR1, RAF, zinc fingers and homeoboxes 2
External IDsOMIM: 609185; MGI: 2683087; HomoloGene: 8968; GeneCards: ZHX2; OMA:ZHX2 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ZHX2
Genomic location for ZHX2
Band8q24.13Start122,781,655 bp[1]
End122,974,510 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for ZHX2
Genomic location for ZHX2
Band15 D1|15 24.01 cMStart57,558,061 bp[2]
End57,703,228 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • superficial temporal artery

  • dorsal motor nucleus of vagus nerve

  • saphenous vein

  • Skeletal muscle tissue of rectus abdominis

  • inferior olivary nucleus

  • internal globus pallidus

  • Skeletal muscle tissue of biceps brachii

  • right ventricle

  • caput epididymis

  • lactiferous duct
Top expressed in
  • knee joint

  • triceps brachii muscle

  • vastus lateralis muscle

  • otolith organ

  • temporal muscle

  • utricle

  • skeletal muscle tissue

  • medial head of gastrocnemius muscle

  • granulocyte

  • sternocleidomastoid muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • protein binding
  • protein homodimerization activity
  • transcription corepressor activity
  • metal ion binding
  • identical protein binding
  • protein heterodimerization activity
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
  • plasma membrane
Biological process
  • regulation of transcription by RNA polymerase II
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • mRNA catabolic process
  • negative regulation of neuron differentiation
  • somatic stem cell population maintenance
  • transcription, DNA-templated
  • retinal bipolar neuron differentiation
  • nervous system development
  • cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22882

387609

Ensembl

ENSG00000178764

ENSMUSG00000071757

UniProt

Q9Y6X8

Q8C0C0

RefSeq (mRNA)

NM_014943
NM_001362797

NM_199449

RefSeq (protein)

NP_055758
NP_001349726

NP_955520

Location (UCSC)Chr 8: 122.78 – 122.97 MbChr 15: 57.56 – 57.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.[5][6][7]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178764 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. ^ Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K (Jul 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.
  7. ^ a b "Entrez Gene: ZHX2 zinc fingers and homeoboxes 2".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3". Gene. 323: 133–40. doi:10.1016/j.gene.2003.09.013. PMID 14659886.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • de Andrade TG, Peterson KR, Cunha AF, et al. (2006). "Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster". Blood Cells Mol. Dis. 37 (2): 82–90. doi:10.1016/j.bcmd.2006.07.003. PMID 16952470.
  • Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
  • Hu S, Zhang M, Lv Z, et al. (2007). "Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis". Neoplasma. 54 (3): 207–11. PMID 17447851.
  • v
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  • 2dmp: Solution structure of the third homeobox domain of Zinc fingers and homeoboxes protein 2
    2dmp: Solution structure of the third homeobox domain of Zinc fingers and homeoboxes protein 2
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