YTHDF3

Protein-coding gene in humans
YTHDF3
Identifiers
AliasesYTHDF3, YTH N6-methyladenosine RNA binding protein 3, DF3
External IDsMGI: 1918850; HomoloGene: 34991; GeneCards: YTHDF3; OMA:YTHDF3 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for YTHDF3
Genomic location for YTHDF3
Band8q12.3Start63,168,553 bp[1]
End63,212,786 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for YTHDF3
Genomic location for YTHDF3
Band3|3 A1Start16,237,376 bp[2]
End16,271,201 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • germinal epithelium

  • Epithelium of choroid plexus

  • tibia

  • parietal pleura

  • superficial temporal artery

  • Skeletal muscle tissue of biceps brachii

  • visceral pleura

  • epithelium of nasopharynx

  • mucosa of paranasal sinus
Top expressed in
  • conjunctival fornix

  • embryonic cell

  • zygote

  • tail of embryo

  • migratory enteric neural crest cell

  • parotid gland

  • genital tubercle

  • secondary oocyte

  • cumulus cell

  • intercostal muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • N6-methyladenosine-containing RNA binding
  • RNA binding
  • ribosome binding
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • positive regulation of translation
  • positive regulation of translational initiation
  • mRNA destabilization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

253943

229096

Ensembl

ENSG00000185728

ENSMUSG00000047213

UniProt

Q7Z739

Q8BYK6

RefSeq (mRNA)
NM_001277813
NM_001277814
NM_001277815
NM_001277816
NM_001277817

NM_001277818
NM_152758

NM_001145919
NM_172677
NM_001358041
NM_001358042
NM_001358043

RefSeq (protein)
NP_001264742
NP_001264743
NP_001264744
NP_001264745
NP_001264746

NP_001264747
NP_689971

NP_001139391
NP_766265
NP_001344970
NP_001344971
NP_001344972

Location (UCSC)Chr 8: 63.17 – 63.21 MbChr 3: 16.24 – 16.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

YTH domain family protein 3 is a protein that in humans is encoded by the YTHDF3 gene.[5][6]

See also

N6-Methyladenosine

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185728 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047213 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: YTHDF3 YTH domain family, member 3".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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