TUBGCP4

Protein-coding gene in the species Homo sapiens
TUBGCP4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3RIP

Identifiers
AliasesTUBGCP4, 76P, GCP-4, GCP4, Grip76, MCCRP3, tubulin gamma complex associated protein 4
External IDsOMIM: 609610; MGI: 1196293; HomoloGene: 8690; GeneCards: TUBGCP4; OMA:TUBGCP4 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for TUBGCP4
Genomic location for TUBGCP4
Band15q15.3Start43,369,221 bp[1]
End43,409,771 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for TUBGCP4
Genomic location for TUBGCP4
Band2 E5|2 60.37 cMStart121,001,135 bp[2]
End121,029,251 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • secondary oocyte

  • buccal mucosa cell

  • ganglionic eminence

  • ventricular zone

  • gonad

  • testicle

  • tibialis anterior muscle

  • epithelium of colon

  • cerebellar hemisphere
Top expressed in
  • ascending aorta

  • spermatocyte

  • tail of embryo

  • genital tubercle

  • aortic valve

  • supraoptic nucleus

  • neural layer of retina

  • internal carotid artery

  • thymus

  • spermatid
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of cytoskeleton
  • microtubule minus-end binding
  • protein binding
  • gamma-tubulin binding
Cellular component
  • cytoplasm
  • microtubule organizing center
  • gamma-tubulin complex
  • cytosol
  • spindle pole body
  • spindle pole
  • recycling endosome
  • equatorial microtubule organizing center
  • membrane
  • microtubule
  • microtubule cytoskeleton
  • cytoskeleton
  • centrosome
Biological process
  • microtubule nucleation by interphase microtubule organizing center
  • microtubule cytoskeleton organization
  • mitotic spindle assembly
  • centrosome duplication
  • cytoplasmic microtubule organization
  • microtubule nucleation
  • meiosis
  • mitotic cell cycle
  • spindle assembly
  • protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27229

51885

Ensembl

ENSG00000137822

ENSMUSG00000027263

UniProt

Q9UGJ1

Q9D4F8

RefSeq (mRNA)

NM_001286414
NM_014444

NM_001290824
NM_153387

RefSeq (protein)

NP_001273343
NP_055259

NP_001277753
NP_700436

Location (UCSC)Chr 15: 43.37 – 43.41 MbChr 2: 121 – 121.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin, gamma complex associated protein 4 is a protein in humans that is encoded by the TUBGCP4 gene.[5] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137822 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027263 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Tubulin, gamma complex associated protein 4".

Further reading

  • Hsu HL, Yeh NH (February 1996). "Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis". Journal of Cell Science. 109 ( Pt 2) (2): 277–88. doi:10.1242/jcs.109.2.277. PMID 8838651.
  • Haren L, Merdes A (May 2002). "Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules". Journal of Cell Science. 115 (Pt 9): 1815–24. doi:10.1242/jcs.115.9.1815. PMID 11956313.
  • Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (November 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Molecular Biology of the Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.
  • Fava F, Raynaud-Messina B, Leung-Tack J, Mazzolini L, Li M, Guillemot JC, Cachot D, Tollon Y, Ferrara P, Wright M (November 1999). "Human 76p: A new member of the gamma-tubulin-associated protein family". The Journal of Cell Biology. 147 (4): 857–68. doi:10.1083/jcb.147.4.857. PMC 2156165. PMID 10562286.
  • Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Molecular Biology of the Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
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