THAP7

Protein-coding gene in the species Homo sapiens
THAP7
Identifiers
AliasesTHAP7, THAP domain containing 7
External IDsOMIM: 609518; MGI: 1916259; HomoloGene: 12293; GeneCards: THAP7; OMA:THAP7 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for THAP7
Genomic location for THAP7
Band22q11.21Start20,999,104 bp[1]
End21,002,196 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for THAP7
Genomic location for THAP7
Band16 A3|16Start17,345,846 bp[2]
End17,349,000 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior pituitary

  • right testis

  • muscle of thigh

  • left testis

  • apex of heart

  • gastric mucosa

  • gastrocnemius muscle

  • left uterine tube

  • right lobe of liver

  • gonad
Top expressed in
  • fossa

  • internal carotid artery

  • primary oocyte

  • external carotid artery

  • motor neuron

  • condyle

  • spermatocyte

  • proximal tubule

  • right kidney

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • C2H2 zinc finger domain binding
  • protein binding
  • metal ion binding
  • protein N-terminus binding
  • nucleic acid binding
  • identical protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nuclear speck
  • chromosome
  • nucleus
  • nuclear membrane
  • intracellular membrane-bounded organelle
Biological process
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80764

69009

Ensembl

ENSG00000184436

ENSMUSG00000022760

UniProt

Q9BT49

Q8VCZ3

RefSeq (mRNA)

NM_030573
NM_001008695
NM_001008696

NM_026909

RefSeq (protein)

NP_001008695
NP_085050

NP_081185

Location (UCSC)Chr 22: 21 – 21 MbChr 16: 17.35 – 17.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

THAP domain-containing protein 7 is a protein that in humans is encoded by the THAP7 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184436 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022760 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
  6. ^ "Entrez Gene: THAP7 THAP domain containing 7".

Further reading

  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Macfarlan T, Parker JB, Nagata K, Chakravarti D (2006). "Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription". Mol. Endocrinol. 20 (2): 335–47. doi:10.1210/me.2005-0248. PMID 16195249.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Macfarlan T, Kutney S, Altman B, et al. (2005). "Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor". J. Biol. Chem. 280 (8): 7346–58. doi:10.1074/jbc.M411675200. PMID 15561719.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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