Solute carrier family 10 member 4

Protein-coding gene in the species Homo sapiens
SLC10A4
Identifiers
AliasesSLC10A4, P4, solute carrier family 10 member 4
External IDsMGI: 3606480; HomoloGene: 15495; GeneCards: SLC10A4; OMA:SLC10A4 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SLC10A4
Genomic location for SLC10A4
Band4p11Start48,483,343 bp[1]
End48,489,526 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SLC10A4
Genomic location for SLC10A4
Band5|5 C3.2Start73,164,226 bp[2]
End73,170,298 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pars reticulata

  • Pars compacta

  • testicle

  • pituitary gland

  • superior vestibular nucleus

  • anterior pituitary

  • endothelial cell

  • prefrontal cortex

  • hypothalamus

  • putamen
Top expressed in
  • neural tube

  • striatum of neuraxis

  • morula

  • anterior horn of spinal cord

  • mesencephalon

  • adrenal gland

  • superior frontal gyrus

  • embryo

  • rhombencephalon

  • autonomic nervous system
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • symporter activity
  • bile acid:sodium symporter activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of synaptic vesicle membrane
  • dopaminergic synapse
  • cholinergic synapse
  • serotonergic synapse
Biological process
  • ion transport
  • transmembrane transport
  • sodium ion transport
  • bile acid and bile salt transport
  • adult behavior
  • regulation of neurotransmitter loading into synaptic vesicle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

201780

231290

Ensembl

ENSG00000145248

ENSMUSG00000029219

UniProt

Q96EP9

Q3UEZ8

RefSeq (mRNA)

NM_152679

NM_173403

RefSeq (protein)

NP_689892

NP_775579

Location (UCSC)Chr 4: 48.48 – 48.49 MbChr 5: 73.16 – 73.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 10 member 4 is a protein that in humans is encoded by the SLC10A4 gene.[5] In mice, it appears to promote acidification of synaptic vesicles containing monoamines, enhancing their uptake, and is co-expressed with VMAT2 and VAChT.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145248 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029219 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Solute carrier family 10 member 4". Retrieved 2016-04-17.
  6. ^ Larhammar M, Patra K, Blunder M, Emilsson L, Peuckert C, Arvidsson E, Rönnlund D, Preobraschenski J, Birgner C, Limbach C, Widengren J, Blom H, Jahn R, Wallén-Mackenzie Å, Kullander K (March 2015). "SLC10A4 is a vesicular amine-associated transporter modulating dopamine homeostasis". Biological Psychiatry. 77 (6): 526–36. doi:10.1016/j.biopsych.2014.07.017. hdl:11858/00-001M-0000-0025-7742-E. PMID 25176177. S2CID 6665524.

Further reading

  • Splinter PL, Lazaridis KN, Dawson PA, LaRusso NF (November 2006). "Cloning and expression of SLC10A4, a putative organic anion transport protein". World Journal of Gastroenterology. 12 (42): 6797–805. doi:10.3748/wjg.v12.i42.6797. PMC 4087434. PMID 17106928.
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