SEC24D

Protein-coding gene in the species Homo sapiens
SEC24D
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

3EFO, 3EG9

Identifiers
AliasesSEC24D, CLCRP2, SEC24 homolog D, COPII coat complex component
External IDsOMIM: 607186; MGI: 1916858; HomoloGene: 40986; GeneCards: SEC24D; OMA:SEC24D - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SEC24D
Genomic location for SEC24D
Band4q26Start118,722,823 bp[1]
End118,838,683 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SEC24D
Genomic location for SEC24D
Band3|3 G1Start123,061,104 bp[2]
End123,159,290 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • jejunal mucosa

  • islet of Langerhans

  • ascending aorta

  • right coronary artery

  • Descending thoracic aorta

  • right lobe of liver

  • smooth muscle tissue

  • body of pancreas

  • tibia
Top expressed in
  • yolk sac

  • calvaria

  • ascending aorta

  • aortic valve

  • seminal vesicula

  • duodenum

  • epithelium of small intestine

  • islet of Langerhans

  • jejunum

  • belly cord
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • SNARE binding
  • zinc ion binding
  • metal ion binding
Cellular component
  • cytoplasm
  • endoplasmic reticulum membrane
  • membrane
  • Golgi membrane
  • endoplasmic reticulum
  • COPII vesicle coat
  • cytosol
  • ER to Golgi transport vesicle membrane
  • cytoplasmic vesicle
Biological process
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • antigen processing and presentation of peptide antigen via MHC class I
  • in utero embryonic development
  • COPII vesicle coating
  • protein transport
  • intracellular protein transport
  • vesicle-mediated transport
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • COPII-coated vesicle cargo loading
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9871

69608

Ensembl

ENSG00000150961

ENSMUSG00000039234

UniProt

O94855

n/a

RefSeq (mRNA)

NM_014822
NM_001318066

NM_027135

RefSeq (protein)

NP_001304995
NP_055637

n/a

Location (UCSC)Chr 4: 118.72 – 118.84 MbChr 3: 123.06 – 123.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene.[5][6][7]

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150961 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039234 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
  7. ^ a b "Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae)".

Further reading

  • Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMC 1592520. PMID 15580264.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Farhan H, Reiterer V, Korkhov VM, et al. (2007). "Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D". J. Biol. Chem. 282 (10): 7679–89. doi:10.1074/jbc.M609720200. PMID 17210573.


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