RNF24

Protein-coding gene in the species Homo sapiens
RNF24
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EP4

Identifiers
AliasesRNF24, G1L, ring finger protein 24
External IDsOMIM: 612489; MGI: 1261771; HomoloGene: 5223; GeneCards: RNF24; OMA:RNF24 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for RNF24
Genomic location for RNF24
Band20p13Start3,927,309 bp[1]
End4,015,558 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for RNF24
Genomic location for RNF24
Band2 F1|2 63.32 cMStart131,139,984 bp[2]
End131,194,812 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • blood

  • pericardium

  • cartilage tissue

  • nipple

  • renal medulla

  • stromal cell of endometrium

  • trigeminal ganglion

  • endothelial cell

  • Descending thoracic aorta
Top expressed in
  • zygote

  • secondary oocyte

  • otolith organ

  • utricle

  • human kidney

  • seminiferous tubule

  • ganglionic eminence

  • hand

  • right kidney

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • ubiquitin protein ligase activity
  • metal ion binding
Cellular component
  • integral component of membrane
  • Golgi membrane
  • membrane
  • Golgi apparatus
  • endomembrane system
Biological process
  • protein polyubiquitination
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11237

51902

Ensembl

ENSG00000101236

ENSMUSG00000048911

UniProt

Q9Y225

Q8BGI1

RefSeq (mRNA)

NM_001134337
NM_001134338
NM_007219
NM_001321749
NM_016502

NM_178607

RefSeq (protein)

NP_001127809
NP_001127810
NP_001308678
NP_009150

NP_848722

Location (UCSC)Chr 20: 3.93 – 4.02 MbChr 2: 131.14 – 131.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ring finger protein 24 is a protein that in humans is encoded by the RNF24 gene.[5][6]

RNF24 binds TRPC6 (603652) and other transient receptor potential cation channel (TRPC) family members and is involved in regulation of intracellular trafficking of TRPCs.[6] In addition, RNF24 contains similarity to the Drosophila goliath protein and thus may function as a transcription factor.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101236 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048911 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ring finger protein 24".
  6. ^ a b Lussier MP, Lepage PK, Bousquet SM, Boulay G (May 2008). "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC". Cell Calcium. 43 (5): 432–43. doi:10.1016/j.ceca.2007.07.009. PMID 17850865.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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