PPP3CA

Protein-coding gene in the species Homo sapiens
PPP3CA
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V

Identifiers
AliasesPPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha, IECEE, IECEE1, ACCIID, DEE91
External IDsOMIM: 114105; MGI: 107164; HomoloGene: 55497; GeneCards: PPP3CA; OMA:PPP3CA - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for PPP3CA
Genomic location for PPP3CA
Band4q24Start101,023,409 bp[1]
End101,348,278 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for PPP3CA
Genomic location for PPP3CA
Band3|3 G3Start136,375,885 bp[2]
End136,643,488 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • endothelial cell

  • middle temporal gyrus

  • Region I of hippocampus proper

  • postcentral gyrus

  • Brodmann area 46

  • entorhinal cortex

  • orbitofrontal cortex

  • external globus pallidus

  • pons
Top expressed in
  • olfactory tubercle

  • hippocampus proper

  • lateral septal nucleus

  • globus pallidus

  • nucleus accumbens

  • anterior amygdaloid area

  • lobe of cerebellum

  • subiculum

  • Region I of hippocampus proper

  • prefrontal cortex
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • phosphoprotein phosphatase activity
  • protein dimerization activity
  • protein serine/threonine phosphatase activity
  • metal ion binding
  • calmodulin binding
  • protein binding
  • protein heterodimerization activity
  • enzyme binding
  • calcium-dependent protein serine/threonine phosphatase activity
  • hydrolase activity
  • cyclosporin A binding
  • calmodulin-dependent protein phosphatase activity
Cellular component
  • membrane
  • plasma membrane
  • calcineurin complex
  • nucleoplasm
  • Z disc
  • mitochondrion
  • sarcolemma
  • nucleus
  • cytosol
  • cytoplasm
  • cytoplasmic side of plasma membrane
  • dendritic spine
  • slit diaphragm
  • cell projection
  • synapse
  • Schaffer collateral - CA1 synapse
  • glutamatergic synapse
Biological process
  • multicellular organismal response to stress
  • negative regulation of insulin secretion
  • protein import into nucleus
  • transition between fast and slow fiber
  • negative regulation of chromatin binding
  • response to amphetamine
  • modulation of chemical synaptic transmission
  • positive regulation of DNA-binding transcription factor activity
  • response to calcium ion
  • Fc-epsilon receptor signaling pathway
  • cardiac muscle hypertrophy in response to stress
  • negative regulation of dendrite morphogenesis
  • skeletal muscle fiber development
  • positive regulation of cardiac muscle hypertrophy in response to stress
  • excitatory postsynaptic potential
  • T cell activation
  • cellular response to glucose stimulus
  • calcium ion transport
  • calcium-mediated signaling
  • dephosphorylation
  • positive regulation of transcription by RNA polymerase II
  • Wnt signaling pathway, calcium modulating pathway
  • positive regulation of cardiac muscle hypertrophy
  • positive regulation of gene expression
  • negative regulation of gene expression
  • negative regulation of production of miRNAs involved in gene silencing by miRNA
  • positive regulation of connective tissue replacement
  • positive regulation of endocytosis
  • G1/S transition of mitotic cell cycle
  • protein dephosphorylation
  • calcineurin-NFAT signaling cascade
  • positive regulation of calcineurin-NFAT signaling cascade
  • brain development
  • positive regulation of cell migration
  • skeletal muscle tissue regeneration
  • positive regulation of cell adhesion
  • calcineurin-mediated signaling
  • postsynaptic modulation of chemical synaptic transmission
  • human ageing
  • peptidyl-serine dephosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5530

19055

Ensembl

ENSG00000138814

ENSMUSG00000028161

UniProt

Q08209

P63328

RefSeq (mRNA)

NM_001130692
NM_000944
NM_001130691

NM_001293622
NM_008913

RefSeq (protein)

NP_000935
NP_001124163
NP_001124164

NP_001280551
NP_032939

Location (UCSC)Chr 4: 101.02 – 101.35 MbChr 3: 136.38 – 136.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA) is a protein that in humans is encoded by the PPP3CA gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138814 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028161 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Universal protein resource accession number Q08209 for "Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform" at UniProt.
  6. ^ "Entrez Gene: Protein phosphatase 3, catalytic subunit, alpha isozyme". Retrieved 2011-12-18.

Further reading

  • Crabtree GR (March 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. S2CID 8817053.
  • Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (April 1999). "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD". Science. 284 (5412): 339–43. Bibcode:1999Sci...284..339W. doi:10.1126/science.284.5412.339. PMID 10195903.
  • Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S (July 2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways". Human Molecular Genetics. 9 (11): 1681–90. doi:10.1093/hmg/9.11.1681. PMID 10861295.
  • Frey N, Richardson JA, Olson EN (December 2000). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196.
  • Siddiq A, Miyazaki T, Takagishi Y, Kanou Y, Hayasaka S, Inouye M, Seo H, Murata Y (May 2001). "Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism". Endocrinology. 142 (5): 1752–9. doi:10.1210/endo.142.5.8156. PMID 11316738.
  • Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (June 2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183. S2CID 5278706.
  • Mukerjee N, McGinnis KM, Gnegy ME, Wang KK (August 2001). "Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation". Biochemical and Biophysical Research Communications. 285 (5): 1192–9. CiteSeerX 10.1.1.414.4108. doi:10.1006/bbrc.2001.5278. PMID 11478781.
  • Volkel H, Scholz M, Link J, Selzle M, Werner P, Tunnemann R, Jung G, Ludolph AC, Reuter A (August 2001). "Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin". FEBS Letters. 503 (2–3): 201–5. doi:10.1016/S0014-5793(01)02730-2. PMID 11513882. S2CID 44432580.
  • Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J (November 2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". The Journal of Experimental Medicine. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752.
  • Frey N, Olson EN (April 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". The Journal of Biological Chemistry. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
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