PIK3R3

Protein-coding gene in the species Homo sapiens
PIK3R3
Identifiers
AliasesPIK3R3, p55, p55-GAMMA, p55PIK, phosphoinositide-3-kinase regulatory subunit 3, PI3KR3
External IDsOMIM: 606076; MGI: 109277; HomoloGene: 2690; GeneCards: PIK3R3; OMA:PIK3R3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PIK3R3
Genomic location for PIK3R3
Band1p34.1Start46,040,140 bp[1]
End46,133,036 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PIK3R3
Genomic location for PIK3R3
Band4|4 D1Start116,078,815 bp[2]
End116,160,253 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • paraflocculus of cerebellum

  • nasal epithelium

  • lower lobe of lung

  • right hemisphere of cerebellum

  • mucosa of paranasal sinus

  • right ventricle

  • right lung

  • testicle

  • ganglionic eminence
Top expressed in
  • cerebellar vermis

  • lobe of cerebellum

  • zygote

  • hand

  • ganglionic eminence

  • otic vesicle

  • inferior colliculus

  • suprachiasmatic nucleus

  • pontine nuclei

  • secondary oocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol 3-kinase regulator activity
  • protein binding
  • 1-phosphatidylinositol-3-kinase activity
  • phosphotyrosine residue binding
  • 1-phosphatidylinositol-3-kinase regulator activity
Cellular component
  • cytosol
  • phosphatidylinositol 3-kinase complex
Biological process
  • regulation of phosphatidylinositol 3-kinase activity
  • phosphatidylinositol-3-phosphate biosynthetic process
  • insulin receptor signaling pathway
  • positive regulation of protein phosphorylation
  • cell migration involved in sprouting angiogenesis
  • positive regulation of gene expression
  • protein kinase B signaling
  • positive regulation of cell migration
  • phosphatidylinositol phosphate biosynthetic process
  • phosphatidylinositol biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8503

18710

Ensembl

ENSG00000117461

ENSMUSG00000028698

UniProt

Q92569

Q64143

RefSeq (mRNA)
NM_001114172
NM_001303428
NM_001303429
NM_001328648
NM_001328649

NM_001328650
NM_001328651
NM_001328652
NM_001328653
NM_001328654
NM_003629

NM_181585
NM_001355584
NM_001355585
NM_001355586

RefSeq (protein)
NP_001107644
NP_001290357
NP_001290358
NP_001315577
NP_001315578

NP_001315579
NP_001315580
NP_001315581
NP_001315582
NP_001315583
NP_003620

NP_853616
NP_001342513
NP_001342514
NP_001342515

Location (UCSC)Chr 1: 46.04 – 46.13 MbChr 4: 116.08 – 116.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.[5][6]


Interactions

PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,[7] IRS1[7][8] and Retinoblastoma protein.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117461 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028698 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene. 209 (1–2): 175–83. doi:10.1016/S0378-1119(98)00045-6. PMID 9524259.
  6. ^ "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)".
  7. ^ a b Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN 0888-8809. PMID 9415396.
  8. ^ Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN 0264-6021. PMC 1220424. PMID 10417350.
  9. ^ Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN 0270-7306. PMC 151709. PMID 12588990.

Further reading

  • Pons S, Asano T, Glasheen E, et al. (1995). "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase". Mol. Cell. Biol. 15 (8): 4453–65. doi:10.1128/MCB.15.8.4453. PMC 230685. PMID 7542745.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Tuscano JM, Engel P, Tedder TF, et al. (1996). "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22". Eur. J. Immunol. 26 (6): 1246–52. doi:10.1002/eji.1830260610. PMID 8647200. S2CID 29471624.
  • Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
  • Mothe I, Delahaye L, Filloux C, et al. (1998). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. PMID 9415396.
  • Xia X, Serrero G (1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. PMC 1220424. PMID 10417350.
  • Inukai K, Funaki M, Anai M, et al. (2001). "Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations". FEBS Lett. 490 (1–2): 32–8. doi:10.1016/S0014-5793(01)02132-9. PMID 11172806.
  • Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Xia X, Cheng A, Akinmade D, Hamburger AW (2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. PMC 151709. PMID 12588990.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Soroceanu L, Kharbanda S, Chen R, et al. (2007). "Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3466–71. Bibcode:2007PNAS..104.3466S. doi:10.1073/pnas.0611271104. PMC 1802005. PMID 17360667.
  • Kallin A, Johannessen LE, Cani PD, et al. (2007). "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma". J. Lipid Res. 48 (7): 1628–36. doi:10.1194/jlr.M700136-JLR200. PMID 17452746.
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    2pna: STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE
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