PIK3CB

Protein-coding gene in the species Homo sapiens

PIK3CB

Identifiers

Aliases

PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

External IDs

OMIM: 602925; MGI: 1922019; HomoloGene: 21250; GeneCards: PIK3CB; OMA:PIK3CB - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q22.3	Start	138,652,698 bp^[1]
Band	3q22.3	End	138,834,928 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 E3.3	Start	98,918,707 bp^[2]
Band	9\|9 E3.3	End	99,022,674 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

internal globus pallidus

endothelial cell

middle temporal gyrus

Epithelium of choroid plexus

Brodmann area 23

lateral nuclear group of thalamus

kidney tubule

optic nerve

pons

Top expressed in

granulocyte

superior cervical ganglion

esophagus

interventricular septum

zygote

facial motor nucleus

morula

secondary oocyte

dentate gyrus of hippocampal formation granule cell

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding 1-phosphatidylinositol-4-phosphate 3-kinase activity protein binding insulin receptor substrate binding ATP binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity kinase activity 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity
Cellular component	cytosol phosphatidylinositol 3-kinase complex plasma membrane nucleolus nucleus midbody cytoplasm membrane intracellular anatomical structure
Biological process	G protein-coupled receptor signaling pathway embryonic cleavage endocytosis positive regulation of autophagy Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway angiogenesis involved in wound healing cellular calcium ion homeostasis regulation of cell-matrix adhesion platelet activation autophagy Fc-epsilon receptor signaling pathway chemotaxis phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process positive regulation of gene expression vascular endothelial growth factor receptor signaling pathway cell adhesion response to wounding endothelial cell proliferation regulation of clathrin-dependent endocytosis T cell receptor signaling pathway platelet aggregation cell migration phosphatidylinositol-mediated signaling leukocyte migration signal transduction homophilic cell adhesion via plasma membrane adhesion molecules axon guidance phosphorylation adaptive immune response inflammatory response positive regulation of neutrophil apoptotic process innate immune response cell chemotaxis positive regulation of protein kinase B signaling phosphatidylinositol 3-kinase signaling cytokine-mediated signaling pathway protein phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling phosphatidylinositol biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5291


74769

Ensembl


ENSG00000051382


ENSMUSG00000032462

UniProt


P42338


Q8BTI9

RefSeq (mRNA)


NM_001256045 NM_006219


NM_029094

RefSeq (protein)


NP_001242974 NP_006210


NP_083370

Location (UCSC)

Chr 3: 138.65 – 138.83 Mb

Chr 9: 98.92 – 99.02 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.^[5]^[6]

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000051382 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032462 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol. 13 (12): 7677–88. doi:10.1128/mcb.13.12.7677. PMC 364839. PMID 8246984.
^ ^a ^b "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide".

Katada T, Kurosu H, Okada T, et al. (1999). "Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors". Chem. Phys. Lipids. 98 (1–2): 79–86. doi:10.1016/S0009-3084(99)00020-1. PMID 10358930.
Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
Carpenter CL, Duckworth BC, Auger KR, et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver". J. Biol. Chem. 265 (32): 19704–11. doi:10.1016/S0021-9258(17)45429-9. PMID 2174051.
Bonnefoy-Bérard N, Liu YC, von Willebrand M, et al. (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. Bibcode:1995PNAS...9210142B. doi:10.1073/pnas.92.22.10142. PMC 40752. PMID 7479742.
Hu P, Schlessinger J (1994). "Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta". Mol. Cell. Biol. 14 (4): 2577–83. doi:10.1128/mcb.14.4.2577. PMC 358625. PMID 8139559.
Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793. S2CID 33397908.
Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID 9394803. S2CID 6303471.
Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID 9446795.
Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi:10.1097/00002030-199811000-00008. PMID 9708406. S2CID 25758704.
Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A. PMID 9808187.
Graness A, Adomeit A, Heinze R, et al. (1998). "A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon". J. Biol. Chem. 273 (48): 32016–22. doi:10.1074/jbc.273.48.32016. PMID 9822674.
Sotsios Y, Whittaker GC, Westwick J, Ward SG (1999). "The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes". J. Immunol. 163 (11): 5954–63. doi:10.4049/jimmunol.163.11.5954. PMID 10570282.
Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi:10.1182/blood.V97.2.352. PMID 11154208.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Yang H, Wang X, Raizada MK (2001). "Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons". Endocrinology. 142 (8): 3502–11. doi:10.1210/en.142.8.3502. PMID 11459796.
Steták A, Csermely P, Ullrich A, Kéri G (2001). "Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta". Biochem. Biophys. Res. Commun. 288 (3): 564–72. doi:10.1006/bbrc.2001.5811. PMID 11676480.
Ueki K, Yballe CM, Brachmann SM, et al. (2002). "Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 419–24. Bibcode:2002PNAS...99..419U. doi:10.1073/pnas.012581799. PMC 117575. PMID 11752399.