PAQR8

Protein-coding gene in the species Homo sapiens
PAQR8
Identifiers
AliasesPAQR8, C6orf33, LMPB1, MPRB, progestin and adipoQ receptor family member 8
External IDsOMIM: 607780 MGI: 1921479 HomoloGene: 32702 GeneCards: PAQR8
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PAQR8
Genomic location for PAQR8
Band6p12.2Start52,361,421 bp[1]
End52,407,777 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PAQR8
Genomic location for PAQR8
Band1|1 A4Start20,960,830 bp[2]
End21,009,874 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • inferior ganglion of vagus nerve

  • globus pallidus

  • internal globus pallidus

  • subthalamic nucleus

  • external globus pallidus

  • medulla oblongata

  • spinal cord

  • ventral tegmental area

  • pons

  • superior vestibular nucleus
Top expressed in
  • lateral geniculate nucleus

  • cerebellar vermis

  • suprachiasmatic nucleus

  • substantia nigra

  • pontine nuclei

  • mammillary body

  • medial geniculate nucleus

  • medial vestibular nucleus

  • medial dorsal nucleus

  • superior colliculus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • steroid hormone receptor activity
  • steroid binding
  • lipid binding
  • signaling receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • Golgi apparatus
  • plasma membrane
Biological process
  • multicellular organism development
  • response to steroid hormone
  • cell differentiation
  • oogenesis
  • steroid hormone mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85315

74229

Ensembl

ENSG00000170915

ENSMUSG00000025931

UniProt

Q8TEZ7

Q80ZE5

RefSeq (mRNA)

NM_133367

NM_028829
NM_001355122

RefSeq (protein)

NP_588608

NP_083105
NP_001342051

Location (UCSC)Chr 6: 52.36 – 52.41 MbChr 1: 20.96 – 21.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Membrane progesterone receptor beta (mPRβ), or progestin and adipoQ receptor 8 (PAQR8), is a protein that in humans is encoded by the PAQR8 gene.[5][6][7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170915 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025931 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suzuki T, Ganesh S, Agarwala KL, Morita R, Sugimoto Y, Inazawa J, Delgado-Escueta AV, Yamakawa K (Nov 2001). "A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein". Biochemical and Biophysical Research Communications. 288 (3): 626–36. doi:10.1006/bbrc.2001.5825. PMID 11676489.
  6. ^ Zhu Y, Rice CD, Pang Y, Pace M, Thomas P (Mar 2003). "Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2231–6. doi:10.1073/pnas.0336132100. PMC 151323. PMID 12574519.
  7. ^ "Entrez Gene: PAQR8 progestin and adipoQ receptor family member VIII".

Further reading

  • Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Molecular Vision. 8: 185–95. PMID 12107412.
  • Zhu Y, Bond J, Thomas P (Mar 2003). "Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2237–42. Bibcode:2003PNAS..100.2237Z. doi:10.1073/pnas.0436133100. PMC 151324. PMID 12601167.
  • Hammes SR (Mar 2003). "The further redefining of steroid-mediated signaling". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2168–70. Bibcode:2003PNAS..100.2168H. doi:10.1073/pnas.0530224100. PMC 151311. PMID 12606724.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (Sep 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.


  • v
  • t
  • e
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists
See also
Receptor/signaling modulators
Progestogens and antiprogestogens
Androgen receptor modulators
Estrogen receptor modulators
List of progestogens


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