OTUD4

Protein-coding gene in the species Homo sapiens
OTUD4
Identifiers
AliasesOTUD4, DUBA6, HIN1, HSHIN1, OTU deubiquitinase 4
External IDsOMIM: 611744; MGI: 1098801; HomoloGene: 35370; GeneCards: OTUD4; OMA:OTUD4 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for OTUD4
Genomic location for OTUD4
Band4q31.21Start145,110,838 bp[1]
End145,180,589 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for OTUD4
Genomic location for OTUD4
Band8 C1|8 37.74 cMStart80,366,247 bp[2]
End80,404,353 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • middle frontal gyrus

  • Brodmann area 10

  • paraflocculus of cerebellum

  • Skeletal muscle tissue of rectus abdominis

  • frontal pole

  • thoracic diaphragm

  • body of tongue

  • biceps brachii

  • cerebellar vermis

  • epithelium of nasopharynx
Top expressed in
  • otic placode

  • Ileal epithelium

  • saccule

  • otic vesicle

  • cumulus cell

  • Gonadal ridge

  • secondary oocyte

  • tail of embryo

  • zygote

  • atrioventricular valve
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • thiol-dependent deubiquitinase
  • peptidase activity
  • cysteine-type peptidase activity
  • protein binding
  • hydrolase activity
  • RNA binding
  • molecular adaptor activity
  • Lys63-specific deubiquitinase activity
Cellular component
  • cellular component
  • nucleus
  • cytoplasm
Biological process
  • protein K48-linked deubiquitination
  • proteolysis
  • immune system process
  • negative regulation of toll-like receptor signaling pathway
  • innate immune response
  • protein K63-linked deubiquitination
  • positive regulation of DNA demethylation
  • regulation of protein K48-linked deubiquitination
  • negative regulation of interleukin-1-mediated signaling pathway
  • protein deubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54726

73945

Ensembl

ENSG00000164164

ENSMUSG00000036990

UniProt

Q01804

B2RRE7

RefSeq (mRNA)

NM_001102653
NM_017493
NM_199324
NM_001366057
NM_001366058

NM_001081164
NM_001256033

RefSeq (protein)

NP_001096123
NP_059963
NP_001352986
NP_001352987

NP_001074633
NP_001242962

Location (UCSC)Chr 4: 145.11 – 145.18 MbChr 8: 80.37 – 80.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

OTU domain-containing protein 4 is a protein that in humans is encoded by the OTUD4 gene.[5][6][7]

Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164164 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036990 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Raineri I, Senn HP (Feb 1993). "HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts". Nucleic Acids Res. 20 (23): 6261–6. doi:10.1093/nar/20.23.6261. PMC 334514. PMID 1475186.
  6. ^ Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K (May 2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors". Cancer Res. 63 (9): 2024–7. PMID 12727813.
  7. ^ a b "Entrez Gene: OTUD4 OTU domain containing 4".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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