Nasal embryonic LHRH factor

Protein-coding gene in the species Homo sapiens
NSMF
Identifiers
AliasesNSMF, HH9, NELF, Nasal embryonic LHRH factor, NMDA receptor synaptonuclear signaling and neuronal migration factor
External IDsOMIM: 608137; MGI: 1861755; HomoloGene: 10648; GeneCards: NSMF; OMA:NSMF - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NSMF
Genomic location for NSMF
Band9q34.3Start137,447,570 bp[1]
End137,459,334 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for NSMF
Genomic location for NSMF
Band2|2 A3Start24,944,367 bp[2]
End24,952,893 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • anterior cingulate cortex

  • right frontal lobe

  • amygdala

  • prefrontal cortex

  • Region I of hippocampus proper

  • ascending aorta

  • dorsolateral prefrontal cortex

  • caudate nucleus

  • Descending thoracic aorta

  • nucleus accumbens
Top expressed in
  • medial dorsal nucleus

  • medial geniculate nucleus

  • lateral geniculate nucleus

  • subiculum

  • anterior amygdaloid area

  • barrel cortex

  • suprachiasmatic nucleus

  • substantia nigra

  • olfactory tubercle

  • prefrontal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium-dependent protein binding
Cellular component
  • cytoplasm
  • apical dendrite
  • perikaryon
  • postsynaptic membrane
  • cell projection
  • nuclear membrane
  • nuclear envelope
  • membrane
  • postsynaptic density
  • nuclear matrix
  • cortical cytoskeleton
  • plasma membrane
  • synapse
  • nucleoplasm
  • cell junction
  • dendrite
  • cell cortex
  • neuron projection
  • cytoskeleton
  • nucleus
Biological process
  • positive regulation of protein dephosphorylation
  • regulation of neuron apoptotic process
  • positive regulation of neuron migration
  • regulation of dendrite morphogenesis
  • cellular response to amino acid stimulus
  • cellular response to gonadotropin stimulus
  • cellular response to electrical stimulus
  • regulation of neuron migration
  • regulation of neuronal synaptic plasticity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26012

56876

Ensembl

ENSG00000165802

ENSMUSG00000006476

UniProt

Q6X4W1

Q99NF2

RefSeq (mRNA)

NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537

NM_001039386
NM_001039387
NM_001177654
NM_001177655
NM_020276

RefSeq (protein)

NP_001124441
NP_001124442
NP_001124443
NP_001171535
NP_056352

NP_001034475
NP_001034476
NP_001171125
NP_001171126
NP_064672

Location (UCSC)Chr 9: 137.45 – 137.46 MbChr 2: 24.94 – 24.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nasal embryonic luteinizing hormone-releasing hormone factor is a protein that in humans is encoded by the NELF gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165802 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006476 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ Kramer PR, Wray S (Jul 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes & Development. 14 (14): 1824–34. doi:10.1101/gad.14.14.1824. PMC 316793. PMID 10898796.
  7. ^ "Entrez Gene: NELF nasal embryonic LHRH factor".

Further reading

  • Miura K, Acierno JS, Seminara SB (2004). "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)". Journal of Human Genetics. 49 (5): 265–8. doi:10.1007/s10038-004-0137-4. PMID 15362570.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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