Minodronic acid

Minodronic acid
Names
Preferred IUPAC name
[1-Hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
Other names
Minodronate; YM 529
Identifiers
CAS Number
  • 180064-38-4 checkY
  • 155648-60-5 (monohydrate) checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL319144 checkY
ChemSpider
  • 115805 checkY
IUPHAR/BPS
  • 3164
PubChem CID
  • 130956
UNII
  • 40SGR63TGL checkY
  • 457X74V7ND (monohydrate) checkY
CompTox Dashboard (EPA)
  • DTXSID4048779 Edit this at Wikidata
InChI
  • InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18) checkY
    Key: VMMKGHQPQIEGSQ-UHFFFAOYSA-N checkY
  • O=P(O)(O)C(O)(P(=O)(O)O)Cc1cnc2ccccn12
Properties
Chemical formula
 C9H12N2O7P2
Molar mass 322.150 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis.[1] Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity.[2]

References

  1. ^ Shridhar Hegde and Michelle Schmidt (2009). "To Market, To Market - 2009. 16. Minodronic acid". Annual Reports in Medicinal Chemistry. 45: 509–510. doi:10.1016/s0065-7743(10)45028-9.
  2. ^ Sorbera, L.A.; Castañer, J.; Leeson, P.A. (2002). "Minodronic Acid". Drugs of the Future. 27 (10): 935–941. doi:10.1358/dof.2002.027.10.701186.
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