Mesoderm development LRP chaperone

Protein-coding gene in the species Homo sapiens
MESD
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2I9S, 2KGL, 2KMI, 2RQK, 2RQM, 3OFH

Identifiers
AliasesMESD, BOCA, MESDC2, mesoderm development candidate 2, mesoderm development LRP chaperone, OI20
External IDsOMIM: 607783; MGI: 1891421; HomoloGene: 11347; GeneCards: MESD; OMA:MESD - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for MESD
Genomic location for MESD
Band15q25.1Start80,946,289 bp[1]
End80,989,828 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for MESD
Genomic location for MESD
Band7 48.35 cM|7 D3Start83,884,466 bp[2]
End83,901,532 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic epithelial cell

  • pancreatic ductal cell

  • corpus epididymis

  • mucosa of ileum

  • nasal epithelium

  • tibia

  • palpebral conjunctiva

  • parotid gland

  • internal globus pallidus

  • germinal epithelium
Top expressed in
  • saccule

  • otic placode

  • supraoptic nucleus

  • ureter

  • otic vesicle

  • medullary collecting duct

  • renal corpuscle

  • vestibular sensory epithelium

  • primitive streak

  • spermatocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • low-density lipoprotein particle receptor binding
  • identical protein binding
  • molecular function
Cellular component
  • plasma membrane
  • endoplasmic reticulum
  • cellular component
Biological process
  • mesoderm development
  • protein folding
  • Wnt signaling pathway
  • phagocytosis
  • protein localization to cell surface
  • positive regulation of skeletal muscle acetylcholine-gated channel clustering
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23184

67943

Ensembl

ENSG00000117899

ENSMUSG00000038503

UniProt

Q14696

Q9ERE7

RefSeq (mRNA)

NM_015154

NM_023403

RefSeq (protein)

NP_055969

NP_075892
NP_001361019

Location (UCSC)Chr 15: 80.95 – 80.99 MbChr 7: 83.88 – 83.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mesoderm development LRP chaperone, or MESD, is a protein that in humans is encoded by the MESD gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117899 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038503 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  6. ^ Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
  7. ^ "Entrez Gene: MESDC2 mesoderm development candidate 2".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hsieh JC, Lee L, Zhang L, et al. (2003). "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity". Cell. 112 (3): 355–67. doi:10.1016/S0092-8674(03)00045-X. PMID 12581525.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Veltman IM, Vreede LA, Cheng J, et al. (2005). "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25)". Hum. Mol. Genet. 14 (14): 1955–63. doi:10.1093/hmg/ddi200. PMID 15917269.
  • Li Y, Lu W, He X, Bu G (2006). "Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd". FEBS Lett. 580 (22): 5423–8. doi:10.1016/j.febslet.2006.09.011. PMID 16989816. S2CID 9683744.
  • v
  • t
  • e
  • 2i9s: The solution structure of the core of mesoderm development (MESD).
    2i9s: The solution structure of the core of mesoderm development (MESD).


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