Matrix metalloproteinase inhibitor
A matrix metalloproteinase inhibitor (INN stem –mastat[1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs.[2] Examples include:
- Batimastat
- Cipemastat
- Ilomastat
- Marimastat
- Prinomastat
- Tanomastat
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria.[3]
See also
References
- ^ "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). World Health Organization. Retrieved 5 November 2016.
- ^ Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations". Science. 295 (5564): 2387–2392. Bibcode:2002Sci...295.2387C. doi:10.1126/science.1067100. ISSN 0036-8075. PMID 11923519. S2CID 19944201.
- ^ Noel Vinay Thomas; Se Kwon Kim (2010). "Metalloproteinase Inhibitors Stts and Scope from Marine Organisms". Biochemistry Research International. 2010: 845975. doi:10.1155/2010/845975. PMC 3004377. PMID 21197102.
- v
- t
- e
Pharmacology: enzyme inhibition
- Competitive inhibition
- Uncompetitive inhibition
- Non-competitive inhibition
- Suicide inhibition
- Mixed inhibition
| Oxidoreductase (EC 1) |
|
|---|---|
| Transferase (EC 2) | |
| Hydrolase (EC 3) |
|
| Lyase (EC 4) | |
| Miscellaneous |
 | This biochemistry article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e
