MRPS5

Protein-coding gene in the species Homo sapiens
MRPS5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J9M

Identifiers
AliasesMRPS5, MRP-S5, S5mt, mitochondrial ribosomal protein S5, 28S ribosomal protein S5, mitochondrial
External IDsOMIM: 611972; MGI: 1924971; HomoloGene: 32726; GeneCards: MRPS5; OMA:MRPS5 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for MRPS5
Genomic location for MRPS5
Band2q11.1Start95,085,369 bp[1]
End95,122,027 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for MRPS5
Genomic location for MRPS5
Band2|2 F1Start127,429,142 bp[2]
End127,448,749 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • pancreatic epithelial cell

  • tibialis anterior muscle

  • right lobe of liver

  • gastrocnemius muscle

  • renal medulla

  • deltoid muscle

  • Brodmann area 9

  • hypothalamus

  • right adrenal gland
Top expressed in
  • ventricular zone

  • embryo

  • muscle of thigh

  • spermatocyte

  • embryo

  • blastocyst

  • right kidney

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • epiblast
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • structural constituent of ribosome
  • RNA binding
Cellular component
  • mitochondrial inner membrane
  • ribosome
  • mitochondrion
  • cytosolic small ribosomal subunit
  • mitochondrial small ribosomal subunit
Biological process
  • mitochondrial translational elongation
  • mitochondrial translational termination
  • protein biosynthesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64969

77721

Ensembl

ENSG00000289685

ENSMUSG00000027374

UniProt

P82675

Q99N87

RefSeq (mRNA)

NM_031902
NM_001321995
NM_001321996
NM_001321997

NM_029963

RefSeq (protein)

NP_001308924
NP_001308925
NP_001308926
NP_114108

NP_084239

Location (UCSC)Chr 2: 95.09 – 95.12 MbChr 2: 127.43 – 127.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene.[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000289685 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027374 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPS5 mitochondrial ribosomal protein S5".

Further reading

  • Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  • Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (Aug 2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". The Journal of Biological Chemistry. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
  • Koc EC, Burkhart W, Blackburn K, Koc H, Moseley A, Spremulli LL (Mar 2001). "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach". Protein Science. 10 (3): 471–81. doi:10.1110/ps.35301. PMC 2374141. PMID 11344316.
  • Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (Jun 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". The Journal of Biological Chemistry. 276 (22): 19363–74. CiteSeerX 10.1.1.501.8919. doi:10.1074/jbc.M100727200. PMID 11279123.

External links

  • Overview of all the structural information available in the PDB for UniProt: P82675 (28S ribosomal protein S5, mitochondrial) at the PDBe-KB.
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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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