MLF1IP

Protein-coding gene in the species Homo sapiens
CENPU
Identifiers
AliasesCENPU, CENP50, CENPU50, KLIP1, MLF1IP, PBIP1, centromere protein U
External IDsOMIM: 611511; MGI: 1919126; HomoloGene: 11629; GeneCards: CENPU; OMA:CENPU - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CENPU
Genomic location for CENPU
Band4q35.1Start184,694,085 bp[1]
End184,734,130 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CENPU
Genomic location for CENPU
Band8|8 B1.1Start47,005,063 bp[2]
End47,033,042 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • oocyte

  • secondary oocyte

  • right testis

  • left testis

  • trabecular bone

  • ventricular zone

  • embryo

  • ganglionic eminence

  • bone marrow
Top expressed in
  • spermatocyte

  • spermatid

  • tail of embryo

  • zygote

  • seminiferous tubule

  • secondary oocyte

  • genital tubercle

  • hand

  • yolk sac

  • epiblast
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • chromosome
  • cytoplasm
  • cytosol
  • chromosome, centromeric region
  • nucleus
  • kinetochore
  • nucleoplasm
  • microtubule organizing center
Biological process
  • chordate embryonic development
  • viral process
  • regulation of transcription, DNA-templated
  • CENP-A containing chromatin assembly
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79682

71876

Ensembl

ENSG00000151725

ENSMUSG00000031629

UniProt

Q71F23

Q8C4M7

RefSeq (mRNA)

NM_024629

NM_027973
NM_001368403

RefSeq (protein)

NP_078905

NP_082249
NP_001355332

Location (UCSC)Chr 4: 184.69 – 184.73 MbChr 8: 47.01 – 47.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein U is a protein that in humans is encoded by the CENPU gene.[5][6][7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151725 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031629 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101. S2CID 1627133.
  6. ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
  7. ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
  8. ^ "Entrez Gene: MLF1IP MLF1 interacting protein".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Zhang YJ, Pan HY, Gao SJ (2002). "Reverse transcription slippage over the mRNA secondary structure of the LIP1 gene". BioTechniques. 31 (6): 1286–1294. doi:10.2144/01316st02. PMID 11768657.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Pan HY, Zhang YJ, Wang XP, et al. (2003). "Identification of a Novel Cellular Transcriptional Repressor Interacting with the Latent Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus". J. Virol. 77 (18): 9758–68. doi:10.1128/JVI.77.18.9758-9768.2003. PMC 224565. PMID 12941884.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hanissian SH, Teng B, Akbar U, et al. (2005). "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma". Brain Res. 1047 (1): 56–64. doi:10.1016/j.brainres.2005.04.017. PMID 15893739. S2CID 30594722.
  • Minoshima Y, Hori T, Okada M, et al. (2005). "The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage". Mol. Cell. Biol. 25 (23): 10315–28. doi:10.1128/MCB.25.23.10315-10328.2005. PMC 1291240. PMID 16287847.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
  • Kang YH, Park JE, Yu LR, et al. (2006). "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation". Mol. Cell. 24 (3): 409–22. doi:10.1016/j.molcel.2006.10.016. PMID 17081991.
  • Suzuki H, Arakawa Y, Ito M, et al. (2007). "MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal". Anticancer Res. 27 (3B): 1423–30. PMID 17595757.


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