Leukotriene B4

Leukotriene B₄

Names
Preferred IUPAC name (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid
Identifiers
CAS Number	71160-24-2 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:15647 N
ChEMBL	ChEMBL65061 N
ChemSpider	4444132 N
IUPHAR/BPS	2487
KEGG	C02165 N
PubChem CID	5280492
UNII	1HGW4DR56D Y
CompTox Dashboard (EPA)	DTXSID4037162
InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 N Key: VNYSSYRCGWBHLG-AMOLWHMGSA-N N InChI=1/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 Key: VNYSSYRCGWBHLG-AMOLWHMGBE
SMILES CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O
Properties
Chemical formula	C20H32O4
Molar mass	336.472 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Leukotriene B₄ (LTB₄) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice.

Biochemistry

LTB₄ is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.^[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells.^[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A₄.^[2]

Diabetes

A study at the University of California, San Diego School of Medicine has shown that LTB₄ promotes insulin resistance in obese mice.^[3] Obesity is the major cause of insulin resistance in type 2 diabetes.^[4]

References