LDB2

Protein-coding gene in the species Homo sapiens
LDB2
Identifiers
AliasesLDB2, CLIM1, LDB1, LDB-2, LIM domain binding 2
External IDsOMIM: 603450; MGI: 894670; HomoloGene: 989; GeneCards: LDB2; OMA:LDB2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for LDB2
Genomic location for LDB2
Band4p15.32Start16,501,541 bp[1]
End16,898,678 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for LDB2
Genomic location for LDB2
Band5|5 B3Start44,629,474 bp[2]
End44,957,022 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lung

  • Brodmann area 23

  • middle temporal gyrus

  • body of uterus

  • superior frontal gyrus

  • vena cava

  • Brodmann area 10

  • primary visual cortex

  • frontal pole

  • Achilles tendon
Top expressed in
  • Gonadal ridge

  • subiculum

  • genital tubercle

  • vas deferens

  • lumbar spinal ganglion

  • dorsomedial hypothalamic nucleus

  • ventromedial nucleus

  • left lung

  • Region I of hippocampus proper

  • left lung lobe
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • enzyme binding
  • LIM domain binding
  • transcription coregulator activity
  • protein binding
Cellular component
  • nucleus
  • transcription regulator complex
  • cell leading edge
  • nucleolus
  • plasma membrane
Biological process
  • regulation of transcription by RNA polymerase II
  • hair follicle development
  • positive regulation of cellular component biogenesis
  • epithelial structure maintenance
  • somatic stem cell population maintenance
  • positive regulation of transcription by RNA polymerase II
  • regulation of kinase activity
  • regulation of cell migration
  • negative regulation of transcription by RNA polymerase II
  • multicellular organism development
  • negative regulation of transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9079

16826

Ensembl

ENSG00000169744

ENSMUSG00000039706

UniProt

O43679

O55203

RefSeq (mRNA)

NM_001130834
NM_001290
NM_001304434
NM_001304435

NM_001077398
NM_001286348
NM_010698
NM_001347349
NM_001359070

NM_001359071

RefSeq (protein)

NP_001124306
NP_001281
NP_001291363
NP_001291364

NP_001070866
NP_001273277
NP_001334278
NP_034828
NP_001345999

NP_001346000

Location (UCSC)Chr 4: 16.5 – 16.9 MbChr 5: 44.63 – 44.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM domain-binding protein 2 is a protein that in humans is encoded by the LDB2 gene.[5][6][7][8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169744 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039706 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Feb 1999). "Selection system for genes encoding nuclear-targeted proteins". Nat Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.
  6. ^ Retaux S, Rogard M, Bach I, Failli V, Besson MJ (Feb 1999). "Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain". J Neurosci. 19 (2): 783–93. doi:10.1523/JNEUROSCI.19-02-00783.1999. PMC 6782204. PMID 9880598.
  7. ^ Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM (Oct 2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2". J Cell Biochem. 78 (4): 558–65. doi:10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I. PMID 10861853. S2CID 84122657.
  8. ^ "Entrez Gene: LDB2 LIM domain binding 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Semina EV, Altherr MR, Murray JC (1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm. Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849. S2CID 28813194.
  • Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2". J. Hum. Genet. 44 (2): 112–5. doi:10.1007/s100380050120. PMID 10083735.
  • Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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