LCORL

Mammalian protein found in Homo sapiens
LCORL
Identifiers
AliasesLCORL, MLR1, ligand dependent nuclear receptor corepressor like
External IDsOMIM: 611799; MGI: 2651932; HomoloGene: 82325; GeneCards: LCORL; OMA:LCORL - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for LCORL
Genomic location for LCORL
Band4p15.31Start17,841,199 bp[1]
End18,021,876 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for LCORL
Genomic location for LCORL
Band5|5 B3Start45,697,181 bp[2]
End45,857,615 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • endothelial cell

  • sperm

  • jejunal mucosa

  • visceral pleura

  • mucosa of ileum

  • tibia

  • parietal pleura

  • pancreatic ductal cell

  • ventricular zone
Top expressed in
  • ventromedial nucleus

  • habenula

  • Rostral migratory stream

  • spermatocyte

  • barrel cortex

  • lumbar spinal ganglion

  • anterior amygdaloid area

  • lateral septal nucleus

  • pineal gland

  • epithelium of small intestine
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • regulation of transcription by RNA polymerase II
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

254251

209707

Ensembl

ENSG00000178177

ENSMUSG00000015882

UniProt

Q8N3X6

Q3U285

RefSeq (mRNA)

NM_001166139
NM_153686

NM_001163073
NM_172153
NM_178142
NM_001359871
NM_001359872

NM_001359873
NM_001359874

RefSeq (protein)
NP_001159611
NP_710153
NP_001352587
NP_001352588
NP_001352589

NP_001352590
NP_001352591
NP_001352592
NP_001352594

NP_001156545
NP_742165
NP_835278
NP_001346800
NP_001346801

NP_001346802
NP_001346803

Location (UCSC)Chr 4: 17.84 – 18.02 MbChr 5: 45.7 – 45.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ligand dependent nuclear receptor corepressor like is a protein that in humans is encoded by the LCORL gene. [5]

Function

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178177 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015882 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ligand dependent nuclear receptor corepressor like". Retrieved 2016-11-11.

Further reading

  • Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/s0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.
  • Sovio, U; Bennett, AJ; Millwood, IY; Molitor, J; O'Reilly, PF; Timpson, NJ; Kaakinen, M; Laitinen, J; Haukka, J; Pillas, D; Tzoulaki, I; Molitor, J; Hoggart, C; Coin, LJ; Whittaker, J; Pouta, A; Hartikainen, AL; Freimer, NB; Widen, E; Peltonen, L; Elliott, P; McCarthy, MI; Jarvelin, MR (March 2009). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLOS Genetics. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
  • Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P (2009). "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size". PLOS Genet. 5 (4): e1000445. doi:10.1371/journal.pgen.1000445. PMC 2661236. PMID 19343178.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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