Heterosubtypic immunity

"Heterosubtypic immunity (HSI) is defined as cross-protection to infection with an influenza A virus serotype other than the one used for primary infection."^[1] In layman's terms: an 'infection with "seasonal" influenza A viruses could induce immunity against unrelated sub-strains.'^[2]

References

^ Huan H. Nguyen et al, Heterosubtypic Immunity to Influenza A Virus Infection Requires a Properly Diversified Antibody Repertoire, Journal of Virology
^ Leicester Mercury Winter flu could help protect kids, 30 October 2009

Influenza

General topics

Research
Vaccine
Treatment
Genome sequencing
Reassortment
Superinfection
Flu season

Viruses

Orthomyxoviridae
Influenza A
Influenza B
Influenza C
Influenza D

Influenza A virus
subtypes

H1N1

Pandemics	1918 (Spanish flu) 1977 (Russian flu) 2009 (Swine flu)
Science	2009 A/H1N1

H5N1

Outbreaks	Croatia (2005) India (2006) UK (2007) West Bengal (2008) 2020s outbreak
Science	Genetic structure Transmission and infection Global spread Vaccine clinical trials Human mortality Social impact Pandemic preparation

H5N8

Outbreaks	2020–2022

Treatments

Antiviral drugs	Adamantane derivatives Amantadine Rimantadine Neuraminidase inhibitor Oseltamivir Laninamivir Peramivir Zanamivir Peramivir (experimental) Umifenovir Baloxavir marboxil
Vaccines	Live attenuated influenza vaccine Brands Pandemrix Audenz

Pandemics and
epidemics

Pandemics	Influenza pandemic (1510) Influenza pandemic (1557) Russian flu (1889–1890) Spanish flu (1918) Asian flu (1957-1958) Hong Kong flu (1968) 1977 Russian flu Swine flu (2009)
Epidemics	Fujian flu (H3N2) 1989–1990 UK outbreak Central Luzon H5N6 (2017)