GUCY1A2

Protein-coding gene in the species Homo sapiens
GUCY1A2
Identifiers
AliasesGUCY1A2, GC-SA2, GUC1A2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2
External IDsOMIM: 601244; MGI: 2660877; HomoloGene: 47953; GeneCards: GUCY1A2; OMA:GUCY1A2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for GUCY1A2
Genomic location for GUCY1A2
Band11q22.3Start106,674,019 bp[1]
End107,018,476 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for GUCY1A2
Genomic location for GUCY1A2
Band9|9 A1Start3,532,778 bp[2]
End3,894,736 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • lateral nuclear group of thalamus

  • visceral pleura

  • saphenous vein

  • postcentral gyrus

  • tail of epididymis

  • lower lobe of lung

  • external globus pallidus

  • vena cava

  • endothelial cell
Top expressed in
  • tail of embryo

  • genital tubercle

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • ventricular zone

  • embryo

  • cerebellar cortex

  • spermatid

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • GTP binding
  • heme binding
  • nucleotide binding
  • phosphorus-oxygen lyase activity
  • lyase activity
  • protein binding
  • guanylate cyclase activity
  • adenylate cyclase activity
Cellular component
  • plasma membrane
  • guanylate cyclase complex, soluble
  • cytoplasm
Biological process
  • signal transduction
  • intracellular signal transduction
  • cyclic nucleotide biosynthetic process
  • cGMP biosynthetic process
  • positive regulation of nitric oxide mediated signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2977

234889

Ensembl

ENSG00000152402

ENSMUSG00000041624

UniProt

P33402

n/a

RefSeq (mRNA)

NM_001256424
NM_000855

NM_001033322

RefSeq (protein)

NP_000846
NP_001243353

n/a

Location (UCSC)Chr 11: 106.67 – 107.02 MbChr 9: 3.53 – 3.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152402 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041624 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630. S2CID 84974514.
  6. ^ "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

Further reading

  • Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". NeuroReport. 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474. S2CID 45536193.
  • Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. Bibcode:2002PNAS...99..507B. doi:10.1073/pnas.012368499. PMC 117590. PMID 11752394.
  • Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
  • Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi:10.1210/jcem.86.2.7409. PMID 11158065.
  • Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
  • Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics. 33 (2): 334–6. doi:10.1006/geno.1996.0208. PMID 8660992.
  • Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi:10.1074/jbc.270.36.21109. PMID 7673142.
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