Protein-coding gene in the species Homo sapiens
| GRIK5 |
|---|
|
| Identifiers |
|---|
| Aliases | GRIK5, EAA2, GRIK2, GluK5, KA2, glutamate ionotropic receptor kainate type subunit 5 |
|---|
| External IDs | OMIM: 600283; MGI: 95818; HomoloGene: 1578; GeneCards: GRIK5; OMA:GRIK5 - orthologs |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 19 (human)[1] |
|---|
| | Band | 19q13.2 | Start | 41,998,321 bp[1] |
|---|
| End | 42,070,206 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 7 (mouse)[2] |
|---|
| | Band | 7 A3|7 13.73 cM | Start | 25,009,849 bp[2] |
|---|
| End | 25,072,346 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - olfactory bulb
- lateral nuclear group of thalamus
- ventral tegmental area
- subthalamic nucleus
- vena cava
- superior vestibular nucleus
- inferior ganglion of vagus nerve
- pons
- external globus pallidus
- Pars compacta
|
| | Top expressed in | - superior frontal gyrus
- primary visual cortex
- dentate gyrus of hippocampal formation granule cell
- entorhinal cortex
- perirhinal cortex
- CA3 field
- neural layer of retina
- olfactory tubercle
- ventricular zone
- primary motor cortex
|
| | More reference expression data |
|
|---|
| BioGPS | 
 | | More reference expression data |
|
|---|
|
| Gene ontology |
|---|
| Molecular function | - glutamate receptor activity
- PDZ domain binding
- kainate selective glutamate receptor activity
- SH3 domain binding
- ion channel activity
- ionotropic glutamate receptor activity
- identical protein binding
- extracellularly glutamate-gated ion channel activity
- ligand-gated ion channel activity
- signaling receptor activity
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
| | Cellular component | - integral component of membrane
- perikaryon
- postsynaptic membrane
- kainate selective glutamate receptor complex
- membrane
- postsynaptic density
- synapse
- cell junction
- terminal bouton
- axon
- dendrite
- neuronal cell body
- endoplasmic reticulum
- neuron projection
- ionotropic glutamate receptor complex
- presynaptic membrane
- nucleus
- plasma membrane
- hippocampal mossy fiber to CA3 synapse
- glutamatergic synapse
- integral component of postsynaptic membrane
- integral component of presynaptic membrane
- integral component of postsynaptic density membrane
| | Biological process | - synaptic transmission, glutamatergic
- regulation of membrane potential
- ion transport
- receptor clustering
- protein retention in ER lumen
- regulation of synaptic vesicle fusion to presynaptic active zone membrane
- ion transmembrane transport
- positive regulation of neuron apoptotic process
- establishment of localization in cell
- ionotropic glutamate receptor signaling pathway
- excitatory postsynaptic potential
- cellular response to glucose stimulus
- chemical synaptic transmission
- modulation of chemical synaptic transmission
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | | |
|---|
| RefSeq (protein) | | |
|---|
NP_032194
NP_001346996
NP_001389776
NP_001389777
NP_001389778 |
|
|---|
| Location (UCSC) | Chr 19: 42 – 42.07 Mb | Chr 7: 25.01 – 25.07 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[5][6]
Function
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[6]
Interactions
GRIK5 has been shown to interact with DLG4[7][8] and GRIK2.[9][10]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105737 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003378 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG, et al. (January 1995). "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A. 91 (25): 11849–53. Bibcode:1994PNAS...9111849S. doi:10.1073/pnas.91.25.11849. PMC 45333. PMID 7527545.
- ^ a b "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5".
- ^ Mehta S, Wu H, Garner CC, Marshall J (May 2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.
- ^ Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J (October 1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron. 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. S2CID 18723258.
- ^ Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (January 1994). "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. 269 (2): 1332–9. doi:10.1016/S0021-9258(17)42262-9. PMID 8288598.
- ^ Ripellino JA, Neve RL, Howe JR (January 1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.
Further reading
- Kamboj RK, Schoepp DD, Nutt S, et al. (1992). "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit". Mol. Pharmacol. 42 (1): 10–5. PMID 1321949.
- Cauley K, Kukekov V, Young D (1997). "Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture". J. Neurosci. Res. 47 (3): 311–21. doi:10.1002/(SICI)1097-4547(19970201)47:3<311::AID-JNR9>3.0.CO;2-L. PMID 9039653. S2CID 13044525.
- Porter RH, Eastwood SL, Harrison PJ (1997). "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia". Brain Res. 751 (2): 217–31. doi:10.1016/S0006-8993(96)01404-7. PMID 9099808. S2CID 9796632.
- Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455. S2CID 23219004.
- Garcia EP, Mehta S, Blair LA, et al. (1998). "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron. 21 (4): 727–39. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460. S2CID 18723258.
- Mehta S, Wu H, Garner CC, Marshall J (2001). "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. doi:10.1074/jbc.M100643200. PMID 11279111.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kohda K, Kamiya Y, Matsuda S, et al. (2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): 27–37. doi:10.1016/S0169-328X(02)00561-2. PMID 12573530.
- Hayes DM, Braud S, Hurtado DE, et al. (2003). "Trafficking and surface expression of the glutamate receptor subunit, KA2". Biochem. Biophys. Res. Commun. 310 (1): 8–13. doi:10.1016/j.bbrc.2003.08.115. PMID 14511640.
- Kamm C, Leung J, Joseph S, et al. (2004). "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene". Mov. Disord. 19 (7): 845–7. doi:10.1002/mds.20095. PMID 15254951. S2CID 20276163.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |
