Cyclin dependent kinase like 1

Protein-coding gene in the species Homo sapiens
CDKL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4AGU

Identifiers
AliasesCDKL1, KKIALRE, P42, cyclin dependent kinase like 1
External IDsOMIM: 603441; MGI: 1918341; HomoloGene: 55805; GeneCards: CDKL1; OMA:CDKL1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for CDKL1
Genomic location for CDKL1
Band14q21.3Start50,326,265 bp[1]
End50,416,461 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for CDKL1
Genomic location for CDKL1
Band12|12 C2Start69,793,622 bp[2]
End69,838,041 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • Achilles tendon

  • canal of the cervix

  • body of uterus

  • ectocervix

  • epithelium of colon

  • muscle layer of sigmoid colon

  • right lobe of thyroid gland

  • left ovary

  • monocyte
Top expressed in
  • right kidney

  • human kidney

  • lumbar subsegment of spinal cord

  • spermatid

  • spermatocyte

  • dentate gyrus of hippocampal formation granule cell

  • blood

  • visual cortex

  • primary visual cortex

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • protein serine/threonine kinase activity
  • ATP binding
  • kinase activity
  • cyclin-dependent protein serine/threonine kinase activity
Cellular component
  • cytoplasm
  • extracellular exosome
  • nucleus
  • nucleoplasm
  • intracellular membrane-bounded organelle
  • ciliary transition zone
Biological process
  • heart development
  • phosphorylation
  • regulation of cell cycle
  • protein phosphorylation
  • regulation of cilium assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8814

71091

Ensembl

ENSG00000100490

ENSMUSG00000020990

UniProt

Q00532

Q8CEQ0

RefSeq (mRNA)

NM_001282236
NM_004196
NM_001367064
NM_001367065

NM_183294

RefSeq (protein)

NP_001269165
NP_004187
NP_001353993
NP_001353994

NP_899117

Location (UCSC)Chr 14: 50.33 – 50.42 MbChr 12: 69.79 – 69.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. [5]

Function

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100490 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020990 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Cyclin dependent kinase like 1". Retrieved 2016-06-07.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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