Codeine methylbromide
Chemical compound
- US: Schedule I
- 7,8-Didehydro-17,17-dimethyl-4,5-α-epoxy-6α-hydroxy-3-methoxymorphinanium bromide
- 125-27-9
Y
- 5362447
- 4515039
N
- 25007U9T7H
- DTXSID10924985
- Interactive image
- C[N+]1(CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O)C.[Br-]
InChI
- InChI=1S/C19H24NO3.BrH/c1-20(2)9-8-19-12-5-6-14(21)18(19)23-17-15(22-3)7-4-11(16(17)19)10-13(12)20;/h4-7,12-14,18,21H,8-10H2,1-3H3;1H/q+1;/p-1/t12-,13+,14-,18-,19-;/m0./s1N
- Key:KIKLDWULAZATJG-YZZSNFJZSA-MN
N
Y (what is this?) (verify)Codeine methylbromide (Eucodin) is the bromomethane (methylbromide) salt of codeine. Its possession is prohibited in many jurisdictions. It is considered a Schedule I controlled substance in the United States, with a DEA ACSCN of 9070 and nil annual aggregate manufacturing quota.[1] as of 2014. As it is used in a different way than basic salts of codeine like the phosphate or hydrochloride owing to its below-mentioned dual action, it is considered to be a different drug related to codeine rather than merely a salt of it in many contexts.[2]
Also known by the genericised trade name eucodeine, and the salt name also sometimes given as methobromide, this drug was first synthesised in Austria-Hungary in 1903. As it is a bromide in addition to a codeine salt, it has a dual mechanism of action and is indicated for pain with insomnia or nervousness and violent coughing.[2] This codeine-based bromide also has morphine, dihydrocodeine, dihydromorphine, hydromorphone, isocodeine, hydrocodone, and other such analogues; also, there are codeine-based barbiturates and salicylates.[3]
References
- ^ "Conversion Factors for Controlled Substances". Diversion Control Division, Drug Enforcement Administration. U.S. Department of Justice.
- ^ a b Lowry WT, Garriott JC (1979). Forensic Toxicology: Controlled Substances and Dangerous Drugs. Boston, MA: Springer US. pp. 176–177. ISBN 978-1-4684-3444-6.
- ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th ed.). Whitehouse Station, N.J.: Merck. 2001. ISBN 978-0-911910-13-1.
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Opioid receptor modulators
(MOR)
(DOR)
(KOR)
(NOP)
| Agonists |
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|---|---|
| Antagonists |
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- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
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- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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