Protein-coding gene in the species Homo sapiens
CETN1 |
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Identifiers |
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Aliases | CETN1, CEN1, CETN, centrin 1 |
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External IDs | OMIM: 603187; MGI: 1347086; HomoloGene: 105668; GeneCards: CETN1; OMA:CETN1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 18 (human)[1] |
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| Band | 18p11.32 | Start | 580,380 bp[1] |
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End | 582,114 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18|18 A1 | Start | 9,615,524 bp[2] |
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End | 9,619,478 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - left testis
- right testis
- sperm
- testicle
- human musculoskeletal system
- muscular system
- muscle
- muscle
- skeletal striated muscle
- muscle of lower limb
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| Top expressed in | - spermatid
- spermatocyte
- seminiferous tubule
- lumbar subsegment of spinal cord
- motor neuron
- tibiofemoral joint
- submandibular gland
- spinal ganglia
- carotid body
- trachea
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - microtubule binding
- calcium ion binding
- G-protein beta/gamma-subunit complex binding
- heterotrimeric G-protein binding
- protein binding
- metal ion binding
| Cellular component | - cytoplasm
- microtubule organizing center
- centrosome
- spindle pole
- cytoskeleton
- photoreceptor connecting cilium
- centriole
- nucleus
| Biological process | - cell cycle
- cellular response to heat
- cell division
- mitotic cytokinesis
- centriole replication
- regulation of centrosome duplication
- calcium-mediated signaling
- regulation of cytokinesis
- microtubule cytoskeleton organization
- nucleotide-excision repair
- mitotic cell cycle
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 18: 0.58 – 0.58 Mb | Chr 18: 9.62 – 9.62 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Centrin-1 is a protein that in humans is encoded by the CETN1 gene.[5][6] It belongs to the centrin family of proteins.
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000177143 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050996 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Errabolu R, Sanders MA, Salisbury JL (Jun 1994). "Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles". J Cell Sci. 107. ( Pt 1): 9–16. doi:10.1242/jcs.107.1.9. PMID 8175926.
- ^ a b "Entrez Gene: CETN1 centrin, EF-hand protein, 1".
External links
Further reading
- Tsang WY, Spektor A, Luciano DJ, et al. (2006). "CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability". Mol. Biol. Cell. 17 (8): 3423–34. doi:10.1091/mbc.E06-04-0371. PMC 1525247. PMID 16760425.
- Zhao ZS, Lim JP, Ng YW, et al. (2006). "The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A". Mol. Cell. 20 (2): 237–49. doi:10.1016/j.molcel.2005.08.035. hdl:10536/DRO/DU:30131061. PMID 16246726.
- Poole E, Strappe P, Mok HP, et al. (2005). "HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET". Traffic. 6 (9): 741–55. doi:10.1111/j.1600-0854.2005.00312.x. PMID 16101678. S2CID 36574274.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lutz W, Lingle WL, McCormick D, et al. (2001). "Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication". J. Biol. Chem. 276 (23): 20774–80. doi:10.1074/jbc.M101324200. PMID 11279195.
- Laoukili J, Perret E, Middendorp S, et al. (2000). "Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro". J. Cell Sci. 113. ( Pt 8) (8): 1355–64. doi:10.1242/jcs.113.8.1355. PMID 10725219.
PDB gallery
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1m39: Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form -
2a4j: Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein |
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