CUL7

Protein-coding gene in humans
CUL7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2JNG

Identifiers
AliasesCUL7, 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7
External IDsOMIM: 609577 MGI: 1913765 HomoloGene: 56683 GeneCards: CUL7
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CUL7
Genomic location for CUL7
Band6p21.1Start43,037,617 bp[1]
End43,053,943 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for CUL7
Genomic location for CUL7
Band17|17 CStart46,961,263 bp[2]
End46,975,290 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • pituitary gland

  • anterior pituitary

  • right uterine tube

  • right adrenal gland

  • right lobe of thyroid gland

  • canal of the cervix

  • left adrenal gland

  • left lobe of thyroid gland

  • ganglionic eminence
Top expressed in
  • saccule

  • yolk sac

  • otic placode

  • belly cord

  • internal carotid artery

  • external carotid artery

  • molar

  • vas deferens

  • dermis

  • calvaria
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin protein ligase binding
Cellular component
  • cytoplasm
  • cytosol
  • centrosome
  • Golgi apparatus
  • microtubule organizing center
  • Cul7-RING ubiquitin ligase complex
  • perinuclear region of cytoplasm
  • anaphase-promoting complex
  • 3M complex
  • cytoskeleton
Biological process
  • Golgi organization
  • ubiquitin-dependent protein catabolic process
  • placenta development
  • mitotic cytokinesis
  • proteolysis
  • vasculogenesis
  • IRE1-mediated unfolded protein response
  • positive regulation of dendrite morphogenesis
  • protein ubiquitination
  • epithelial to mesenchymal transition
  • viral process
  • microtubule cytoskeleton organization
  • regulation of mitotic nuclear division
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9820

66515

Ensembl

ENSG00000044090

ENSMUSG00000038545

UniProt

Q14999

Q8VE73

RefSeq (mRNA)

NM_001168370
NM_014780
NM_001374872
NM_001374873
NM_001374874

NM_025611

RefSeq (protein)

NP_001161842
NP_055595
NP_001361801
NP_001361802
NP_001361803

NP_079887

Location (UCSC)Chr 6: 43.04 – 43.05 MbChr 17: 46.96 – 46.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[5][6][7]

Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000044090 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038545 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
  6. ^ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60. Bibcode:2003PNAS..100.9855A. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573.
  7. ^ "Entrez Gene: CUL7 cullin 7".

Further reading

  • Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene". Cancer Res. 67 (20): 9616–22. doi:10.1158/0008-5472.CAN-07-0644. PMID 17942889.
  • Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. Bibcode:2007PNAS..10411388J. doi:10.1073/pnas.0609467104. PMC 2040908. PMID 17586686.
  • Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
  • Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.
  • Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID 16875676.
  • Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function". Oncogene. 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID 16547496. S2CID 36894787.
  • Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID 16142236. S2CID 44003147.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  • Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

External links

  • GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
  • OMIM entries entry on 3-M syndrome
  • Human CUL7 genome location and CUL7 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: Q14999 (Human Cullin-7) at the PDBe-KB.


  • v
  • t
  • e
  • 2jng: Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.
    2jng: Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.


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