CLEC9A

Protein-coding gene in humans
CLEC9A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3VPP

Identifiers
AliasesCLEC9A, DNGR1, UNQ9341, CD370, DNGR-1, C-type lectin domain family 9 member A, C-type lectin domain containing 9A
External IDsOMIM: 612252; MGI: 2444608; HomoloGene: 52106; GeneCards: CLEC9A; OMA:CLEC9A - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CLEC9A
Genomic location for CLEC9A
Band12p13.2Start10,030,678 bp[1]
End10,066,031 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for CLEC9A
Genomic location for CLEC9A
Band6|6 F3Start129,385,825 bp[2]
End129,401,726 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • gonad

  • lymph node

  • C1 segment

  • substantia nigra

  • monocyte

  • smooth muscle tissue

  • appendix

  • thymus

  • gallbladder
Top expressed in
  • spleen

  • lung

  • granulocyte

  • liver

  • ovary

  • embryo

  • bone marrow

  • thymus

  • ileum

  • jejunum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • carbohydrate binding
Cellular component
  • integral component of membrane
  • membrane
  • cell surface
Biological process
  • endocytosis
  • receptor-mediated endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

283420

232414

Ensembl

ENSG00000197992

ENSMUSG00000046080

UniProt

Q6UXN8

Q8BRU4

RefSeq (mRNA)

NM_207345

NM_001205363
NM_001205364
NM_001205365
NM_172732

RefSeq (protein)

NP_997228

NP_001192292
NP_001192293
NP_001192294
NP_766320

Location (UCSC)Chr 12: 10.03 – 10.07 MbChr 6: 129.39 – 129.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-type lectin domain family 9 member A is a protein that in humans is encoded by the CLEC9A gene.[5]

Function

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197992 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046080 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: C-type lectin domain family 9 member A". Retrieved 2016-06-02.
  6. ^ Zanders, Edward D. (2015-11-09). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. ISBN 978-1-118-84985-9.

Further reading

  • Huysamen C, Willment JA, Dennehy KM, Brown GD (2008). "CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes". J. Biol. Chem. 283 (24): 16693–701. doi:10.1074/jbc.M709923200. PMC 2562446. PMID 18408006.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human C-type lectin domain family 9 member A (CLEC9A)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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